Distribution Characteristics And Related Factors Of TCM Syndromes In Patients With Colorectal Adenomatous Polyps

ObjectiveTo observe the distribution of common syndromes in patients with colorectal adenomatous polyps and analyze the correlation factors of colorectal adenomas and its relationship with the syndromes.From the perspective of syndromes,we can enrich the syndrome differentiation of colorectal adenomas and trace the pathological mechanism.We hope to provide new research basis for the diagnosis and treatment of colorectal adenomas in Chinese and Western medicine,and provide some guidance for clinical medication and to improvement of healing.MethodsCollected 184 patients information of endoscopic and pathologic diagnosis of colonic polyps from May 2017 to March 2018 in Beijing University of Chinese medicine Third Affiliated Hospital.Containing general information,endoscopic and pathologic results and clinical information.Fill in the "TCM Symptom Acquisition Scale" and the collected data is used to cluster the syndromes.Classification of common syndromes and gender,age,colonoscopy results and pathology results data,using SPSS21.0 for statistical analysis,P<0.05 was statistical significance.Results1.Among the 184 patients with colorectal adenomatous polyp in this study,there were 94 males and 90 females.The onset age of male ranged from 26 to 89 years old,with an average onset age of 59.22±12.10 years,and the onset age of female ranged from 16 to 83 years old,with an average onset age of 59.01±11.53 years.The ratio was 1.04:1.Statistically,there was no significant correlation between gender and adenomas.The average age of the disease was 58,80±12.54,the minimum age was 16,and the maximum age was 89.The peak age ranges from 51 to 60 years and from 61 to 70 years.Patients over 40 years old accounted for 92.93%.Age was associated with the onset of the disease.2.The 184 patients with less than 0.5cm in the smallest adenoma the most common,followed by small adenomas with 0.6cm to 1.0cm,and large adenomas with more than 1.0cm was rare.Morphologically,sessile adenomas is the most common type of adenomas,adenomyoma followed by with the least pedicled one.The sigrnoid colon adenomas were the best,followed by transverse colon adenomas,descending colon one and rectum one.As the patient ages,the incidence of the right colon increases.There was no correlation between the site of adenoma,adenomas morphology,number and age or gender,and there was no correlation between the incidence of adenoma and gender.3.In this study,the polyps of 184 patients were most with tubular adenomas,tubular-villous adenoma followed by villous adenoma at least.All tubular adenomas,tubular-villous adenomas and villous adenomas were accompanied by atypical hyperplasia of different degrees.It is mainly accompanied by mild and moderate atypical hyperplasia.Adenomatoid hyperplastic polyps are not accompanied by atypical hyperplasia.There was no correlation between the pathological classification of adenomatous polyps and age or sex.4.1n the aspect of TCM syndromes,disease status syndrome proportion of order from large to small is spleen>intestine>liver>kidney>stomach,the empiricl syndrome proportion of order from large to small is wetness>bloody stasis>heat>stagnation>cold>sputum>dryness and the deficiency syndrome is qi deficiency>blood deficiency>Yang deficiency>Yin deficiency,disease status syndrome are mainly spleen intestine is secondary,The solidfebrile syndrome is mainly wet,and blood stasis,heat and qi stagnation followed.The deficiency syndrome is dominated by qi deficiency.The young and middle-aged patients with empiricl syndrome were mainly wetness,and the elderly patients were mainly blood stasis,which was not related to gender.Sessile adenomatous polyps and lati adenomas one is mainly wet,and pedicled one is mainly blood stasis.There was no correlation between disease status syndrome,the deficiency syndrome and age or sex.There was no correlation between the above 16 types of TCM syndromes and the number of adenoma.Disease position syndrome in spleen is closely related to moisture,heat,blood stasis,and qi stagnation,disease location is closely associated with wet and hot,diseases status in liver is close to qi stagnation,and closely related to deficiency and blood stasis disease.5.The results of clustering analysis showed that the five kinds of syndromes,firstly,disease-site syndrome was spleen and pathogenic syndrome were qi deficiency and blood stasis.Secondly the disease-site syndrome was intestinal and pathogenic syndrome were wet and hot.Thirdly,disease-site syndrome was liver and pathogenicity syndrome was qi stagnation.Forthly,disease-site syndrome was kidney and pathogenicity syndrome was yang deficiency.Lastly,disease-site syndrome was stomach and pathogenic syndrome was cold.The syndromes can be developed for five types of spleen deficiency and blood stasis,dampness and heat intestines,liver qi stagnation,cold spleen and stomach and spleen and kidney Yang deficiency.ConclusionsThere was no significant difference in the incidence of colorectal adenomas between men and women.After the age of 40,the detection rate of colorectal adenomas patients was higher,and the site of colorectal adenomas polyps was sigmoid colon.Multiple adenomas are more likely to the small adenomas which are less than 0.5cm,and sessile adenomatous polyps is more frequent.The pathological type was mainly tubular adenoma with different degrees of atypical hyperplasia.Colorectal adenomatous disease-site syndrome is characterized by spleen and intestine secondary.solid syndrome is mainly wet,blood stasis,heat and qi stagnation are secondary.The deficiency syndrome is mainly qi deficiency.The relationship between the young and middle-aged members and the qi deficiency is close,and the elderly patients have close relationship with blood stasis.Sessile adenomatous polyps and lati adenomas is mainly wet,and pedicles with blood stasis.After cluster analysis,the combination rule of the syndrome is five kinds of results,firstly,disease-site syndrome was spleen and pathogenic syndrome were qi deficiency and blood stasis.Secondly,the disease-site syndrome was intestinal and pathogenic syndrome were wet and hot.Thirdly,disease-site syndrome was liver and pathogenicity syndrome was qi stagnation.Forthly,disease-site syndrome was kidney and pathogenicity syndrome was yang deficiency.Lastly,disease-site syndrome was stomach and pathogenic syndrome was cold.The syndromes can be developed for five types of spleen deficiency and blood stasis,dampness and heat intestines,liver qi stagnation,cold spleen and stomach and spleen and kidney Yang deficiency.