Clinical Observation Of Jianpi Tongluo Recipe On Prevention And Treatment Of Oxaliplatin Neurotoxicity

Object:To observe the prevention and therapeutic action of Chinese medical prescription of reinforcing spleen and promoting the circulation of blood to reduce the neurotoxicity of Oxaliplatin.Methods:Collected colorectal cancer patients being treated with Oxaliplatin-based chemotherapy from Department of oncology,China-Japan Friendship Hospital,which were divided into treatment group(21 cases)and control group(20 cases).The treatment group accepted tradition Chinese medical and chemotherapy,while the patients in control group were given Mecobalamin Tablets(500 mg each time,three times a day)and chemotherapy.Before the first chemotherapy and two-weeks-chemotherapy in 3,6,8 cycle(three-weeks-chemotherapy in 2,4,6 scheme),observed and recorded the grade of neurotoxicity under the dedicated neurotoxic grading standard of levi,other indexs such as the cumulative doses of Oxaliplatin,tradition Chinese medicine syndrome score,the score of quality of life based FACT-C,degree of side effect caused by chemotherapy according to the NCI toxicity classification standard including hematologic toxicity,hepatic and renal toxicity,cardiotoxity,gastrointestinal reaction were recorded as well.We also collected the basic informations such as age,tumer stages,pathology types,primary origins,diabetes or not and therapeutic regiments.Exce12010 and SPSS22.0 were used to analyze the data.Results:There were no significant differences between the treatment group and the control group in age,gender,tumor primary location,staging,chemotherapy,targeted therapy,the cumulative doses of Oxaliplatin etc.The neurotoxicity of Oxaliplatin had significant difference at third time point during chemotherapy(P<0.05),no significant difference between the first time point and the second time point(P>0.05),the two groups both had no IV neurotoxicity.At the three time points,the leucopenia and neutropenia of two groups had significant differences(P<0.05),the platelet and hemoglobin in no significant difference at the three points(P>0.05),and the hemoglobin averages were an the rise.the liver and kidney toxicity,cardiac toxicity had no significant differences.There were significant differences in the incidence of vomiting at second and third time points after treatment in the two groups.There were statistical differences in the occurrence of diarrhea at third time points,and there was a statistically significant difference in the occurrence of constipation at second time points.There were significant differences between the two groups of TCM syndrome scores at second and third time points after chemotherapy(P<0.05).The scores of quality of life by FACT-C scale in dimensions of body condition,emotional status,functional status,additional attention status changed significantly after treatment(P<0.05),the two groups had significant difference in body condition and additional attention status(P<0.05).The effect of chemotherapy had no significant differences between the two groups(P>0.05).Age,tumor stage,liver metastasis,the history of diabetes,chemotherapy regimens and the cases combined with bevacizumab treatment had no obvious correlation with neurotoxicity(P>0.05),the cumulative dose of Oxaliplatin was significantly correlated with neurotoxicity(P<0.05),and the incidence of neurotoxicity increased with increasing cumulative dose.Conclusion:The method of reinforcing spleen and promoting the circulation of blood was effective in prevention and treatment of Oxaliplatin-induced Neurotoxicity and myelosuppression.It could significantly allevate the symptoms and improve the quality of life.And the neurotoxicity of oxaliplatin was significantly related to its cumulative dose.