Study On Cobalt-Catalyzed Isocyanides Insertion Reactions

In the new drug research and development,natural product synthesis and materials science and many other fields of nitrogen heterocyclic compounds exist and its wide range of applications.Researchers have long been committed to the synthesis of N-containing heterocyclic compounds with special functions.Isocyanide is a kind of special organic synthesis,plays an important role in organic synthesis.In recent years,transition metal-catalyzed isocyanide incorporation has gradually become a hotspot in isocyanide research,and our work is also underway.In this paper,we study the isocyanide insertion reaction catalyzed by transition metal Co(II),and reacted with functionalized substrates to construct a variety of N-containing heterocyclic compounds.The content of this paper mainly includes the following two parts:The first chapter,A series of 2-aminoquinolines are afforded by Co(acac)2 catalyzed isocyanide insertion with 2-vinylanilines under O2 atmosphere.This reaction not only uses low toxicity Co(acac)2 as the catalyst and oxygen as the oxidant,but also a new C(sp2)-C(sp2)bond and a new C(sp2)-N bond are constructed via single-step.The second chapter,We can synthesize pyrrolo[1,2-a]quinoxalines by moderate to good yields by the addition of 2-(1H-pyrrole-1-yl)aniline under the catalysis of cheap green transition metal cobalt derivative.This work provides a new method for the synthesis of pyrrolo[1,2-a]quinoxaline compounds.The reaction uses different isonitrile to give different products.When p-toluenesulfonylmethyl isonitrile is used,the isonitrile serves as a source of Cl to provide carbon atoms in the methylene group.This reaction mechanism is very special,with the value of further research.