| The dissertation consists of two parts:(1)the study of the oxidation of aldehydes at low concentrations to carboxylic acids,(2)the study of the addition of certain groups to the molecules of the indole structure to enhance its biological activity.The first part of this thesis is related to the study of low concentration of aldehyde oxidized to carboxylic acid,developed the first example of catalyst-free aerobic oxidation of aldehydes in water under acidic,neutral and basic pH conditions.In this scenario,one atmosphere of O2 was used as the sole oxidant to oxidize aldehydes to the corresponding carboxylic acids,covering more than ten different aldehydes,and most carboxylic acids yielded yields greater than 99%,does not require any organic reagents,does not require the addition of any catalyst,and the overall reaction is simple.No by-product formation was observed during or after the reaction by high performance liquid chromatography(HPLC)analysis.At the same time,we performed five control reactions to explain why the oxidation rate became slower with increasing temperature and introduced the Fe 3+/Fe 2+recirculation system to accelerate the rate of aldehyde oxidation.In the second part of this paper,the research on the purpose of improving the biological activity of indole compounds is proposed.Monoclonal antibodies are substances that can produce specific antibodies against a single antigenic determinant.Targeted for the detection of certain pathogens,adding some active groups to the structure of indole,making them easy to couple with proteins,The product after the coupling reaction was injected into mice and reacted in mice to produce antibodies,and the monoclonal antibodies required by humans were selected after screening.We mainly connect epichlorohydrin and 4-bromobutyronitrile to the structure of indole acetic acid and its derivatives.The two substrates are synthesized by a simple reaction,the reaction conditions are mild,and the product post-processing operation is simple. |
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