Studies On Preparation Technology And Application Performance Of Ginseng Niosome Cosmetics

Objective: Panax ginseng C.A.Meyer,the dry root of the ginseng of the Araliaceae plant.Ginseng saponins,polysaccharides and amino acids are the main active substances in ginseng.Studies have shown that ginseng has many pHysiological activities such as anti-tumor,anti-oxidation and anti-aging,adjustment of physiological functions and enhancement of immunity of the body.Among them,the skin has moisturizing,anti-oxidation and anti-aging effects,which are recognized and applied by researchers at home and abroad..In addition,liposome as a new drug delivery system has better skin permeability and absorption,and encapsulates ginseng total saponins in a double-layer membrane structure,which is extremely promising and promising in cosmetics.Methods: In this paper,pyrogallol autooxidation method was used to investigate the antioxidant activity of ginseng liposomes.Adult dermal fibroblasts were used as skin cell model,and ginseng liposomes were used to investigate adult dermal fibroblasts(HDF-a)by SRB method.Safety;through the single factor investigation of key raw materials such as base oils and auxiliary materials,the antioxidants and moisturizing properties are used as evaluation indexes to select the optimal formula and the proportion of addition;the ginseng liposome cosmetics(ginseng)The best preparation process of facial cleanser,ginseng toner,ginseng essence,ginseng lotion,ginseng cream,ginseng eye cream;according to "Safety Technical Specifications for Cosmetics"(2015 edition)and quality evaluation of series cosmetics,including appearance traits,trial users Sensory evaluation,heavy metal and microbial detection,pH determination,stability test research.Results: The ginseng liposome has good antioxidant activity.When the concentration is 5%,the scavenging rate of superoxide anion radical can reach 55.1%,and the antioxidant capacity is strong.The ginseng liposome is proved by SRB method.5~1280?g/ml,no toxicity to HDF-a cells;according to the results of pre-experimental and single-factor investigations,the formulation formula of six products in ginseng cosmetics and the best selection of key raw materials were screened by factors such ascomprehensive formulation cost.Determination;the best preparation process of ginseng cosmetics;cosmetics appearance characteristics in line with cosmetic specifications,sensory effect test results are good,non-irritating;detection of total number of colonies,heat-resistant coliform,Pseudomonas aeruginosa,Staphylococcus aureus Five kinds of microorganisms,mold and yeast,and four heavy metal substances such as mercury,lead,arsenic and cadmium were tested.The test results were all qualified.Five batches were randomly selected from each product to determine the pH value.The results were all4.5~8.5,it meets the cosmetic pH range;the stability test is stable after three months of cold and heat resistance test and five cycles of accelerated cycle test.Conclusion:The ginseng liposome was added as an antioxidant functional raw material to cosmetics;the formula,the best ratio and the best preparation process of the six products in ginseng cosmetics were determined through pre-experiment and single factor investigation of key raw materials;ginseng makeup The product has good appearance and sensory effect,no irritation to the skin,the pH value meets the requirements,and the stability is good;the test results of the five microorganisms and the four heavy metals are all qualified.Therefore,the ginseng liposome cosmetics market has certain application prospects.This paper provides a theoretical basis and experimental basis for the development of ginseng liposome cosmetics.