| Surgical dressings,one of the most important ways for drug delivery,have attracted considerable attention.However,the drawbacks of biomedical dressings,such as simple drug loading form,inferior air breathability and terrible drug transdermal efficiency,limit further development of medical dressings in practical application.Poly(ionic liquid)s(PILs),comprised of a polymeric backbone and an ionic liquid(IL)species,are polymerized ionic liquids with special inherent conductivity and high chemical stability.Nowadays,the imidazolium,pyrrolidinium and quaternary ammonium cations based PILs have been widely used in the field of biomedical engineering.Moreover,the broad-spectrum antibacterial properties of the PILs have gained a great deal of attention.How to take full advantage of the PILs properties to obtain functional biomaterials becomes the biggest challenge of biomaterial design.Therefore,aimed at treating different diseases,we synthesized a series of crosslinked materials based on imidazolium PILs with different material forms.The main contents and conclusions are as follows:1.Synthesis of redox-responsive ferrocene-containing poly(ionic liquid)s membranes for antibacterial applications.Ferrocene(Fc)was introduced into the ILs and PILs membranes to obtain antibacterial materials with tunable antibacterial activity through electrochemical redox reaction,the mechanism of the antibacterial activities of ferrocene was systematically investigated.The introduction of Fc groups obviously enhanced the antibacterial efficiency of the Fc-containing ILs because of the generation of reactive oxygen species(ROS).The electrochemical oxidation of Fc to Fc+ and the formation of inclusion complexes between Fc and ?-CD via host-guest interactions decreased the antibacterial activities of ILs and PIL membranes.The antibacterial activities may be recovered in some extent upon the electrochemical reduction of Fc+to Fc or the exclusion of the Fc out of the cavity of ?-CD.In addition,it should be noted that all the Fc containing membranes showed excellent biocompatibility.2.Synthesis of salicylic acid loaded microneedle patches based on imidazolium-type poly(ionic liquid)s for anti-acne.Microneedle(MN)patches have been identified as an ideal material to achieve drug transdermal release.The salicylic acid loaded microneedle patches with reusability for treating acne painlessly were synthesized.The MN patches were stable,and there was no obvious structural degradation after immering the MN patches into PBS solution over 30 days.In addition,the salicylic acid loaded MNs with excellent broad-spectrum antibacterial properties(against both E.coli and S.aureus)could realize the transdermal release over 48 h.Simultaneously,the synthesized MN patches showed excellent antibacterial activity against P.acnes,which makes it possible to effectively inhibit the acne.Therefore,the synthesized MN patches with great biocompatibility provide an efficient and painless approach for acne. |
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