Preparation And Application Of Multifunctional Nanocomposites Of Prussian Blue And Manganese Oxide

As we all know,cancer has been a historical problem that perplexes and threatens human health.It is the most effective way to achieve early diagnosis and treatment in cancer control and treatment.How to achieve early diagnosis and treatment has become a research hotspot in this field.With the rapid development of nanoscience and technology,many cancer treatment methods have been developed.Photothermal therapy is a new cancer treatment method in recent years.Photothermal therapy combining with traditional cancer treatment,such as chemotherapy,can reduce the damage to normal tissues,and improve the therapeutic effect of photothermal therapy on large cancer areas.At the same time,with the development of nanoscience and technology,the nanomaterials with different properties can be combined to realize cancer theranostics.In this paper,we employed prussian blue?PB?as photothermal reagent and manganese oxide with enhanced imaging performance to prepare nanoparticles?NPs?with two different structures,endowing them with drug loading capacity to realize the cancer theranostics.The details are as follows:?1?The PB/MnO₂ core-shell NPs with open cage structure was prepared,which posessed pH,near infrared?NIR?and glutathione?GSH?responses.The obtained NPs had effective photothermal efficiency?31%?,high loading of doxorubicin?DOX,93%?and pH and NIR responsive drug delivery property.At the same time,in GSH environment,MnO₂ attached on the PB surface can be rapidly decomposed into Mn²⁺,thus enhancing the effect of MRI.In addition,the cytotoxicity and the combined chemo-photothermal therapy of the as-prepared core-shell NPs were investigated,suggesting the good biocompatibility and effective treatment.?2?The PB/PAA@MnO?OH?₂ NPs with Janus structure was obtained by growing PAA@MnO?OH?₂ spheres on one side of PB NPs by a simple method.The as-synthesized Janus NPs exhibited the high photothermal conversion efficiency,the loading of positively charged with DOX into the negatively charged PAA and the enhanced MRI imaging ability of MnO?OH?₂.In addition,PB/PAA@MnO?OH?₂ Janus NPs can release DOX under the pH/NIR conditions.Owing to the special structure,the Janus NPs acheived high DOX loading capacity?95 %?,high hotothermal conversion efficiency?40%?and outstanding MRI imaging ability.Further in vitro experiments showed that the PB/PAA@MnO?OH?₂ Janus NPs had good MRI imaging ability and the effective combined chemo-photothermal therapy of cancer cells.