Binaphthol Derivatived As Chiral Stationary Phases For Capillary Electrochromatography

The R-binaphthol has an axial chirality,which is often used as a chiral source to synthesize a series of derivatives.Most of the derivatives can be used as the stationary phase by coating on the inner wall of the capillary column for capillary electrochromatography.The main work of this dissertation is as follows:1.The R-3,3'-di-p-cyanophenyl-2,2'-dimethoxyl-1,1'-binaphthalene was synthesized and used as a stationary phase of enantioseparation.The concentration and the pH of the buffer solution were discussed for capillary electrochromatography.The experimental results shown that five chiral drugs were recognized.2.The R-3,3'-di-p-acetylphenyl-2,2'-dimethoxy-1,1'-binaphthalene was also synthesized as a stationary phase of capillary electrochromatography.Four chiral compounds and one amino acid were separated.3.After synthesized the R-3,3'-di-p-cyanophenyl-2,2'-dihydroxy-1,1'-binaphthalene,the capillary chiral column was prepared.Some experimental parameters of electrochromatography were optimized.Six chiral compounds on the chiral column were resolved.4.The coated capillary column with the R-3,3'-6,6'-tetraacetylphenyl-2,2'-dimethoxyl-1,1'-binaphthalene can separate four chiral compounds.