| Since the 21 st century,sub-health problems caused by low immunity have been the main health problems that threaten humans.The main symptoms and clinical manifestations of sub-health are fatigue and decreased vitality.The incidence rate is increasing year by year.Therefore,in view of the increasing number of sub-health problems that plague our modern human immune system,this article specifically studies a Rhodiola cordyceps militaris tablet that can enhance human immunity.The food is mainly composed of Rhodiola rosea,Cordyceps militaris and Angelica sinensis.They follow the supplementary compatibility theory of traditional Chinese medicine to achieve the health effect of enhancing and improving the body's own immunity.The best compatibility ratio of Rhodiola Angelica sinensis was determined to be 3g: 3g by optimizing the efficacy of Rhodiola Angelica sinensis.According to the new resource food regulations and the review of a large number of documents,it is confirmed that 1.8g of Cordyceps militaris powder(irradiated)is safe and non-toxic and has the effect of enhancing the immunity of the body.3g,Cordyceps militaris powder 1.8g.A single factor was used to investigate the effect of ethanol concentration on the extraction of Rhodiola rosea.Considering food safety,60% ethanol was determined as the optimal extraction concentration.Orthogonal experiment investigated solvent dosage,extraction times and extraction time,and determined the best extraction conditions of Rhodiola rosea for 10 times 60% ethanol,3 extractions,1 hour each time,and extraction conditions of Angelica sinensis for 10 times water extraction3 The extraction time is 2h,1h,and 1h.At the same time,the preparation research was carried out.The auxiliary materials maltodextrin,silicon dioxide and magnesium stearate were added to determine the pilot test process.The pilot test scale-up production research showed that the product extraction and molding process were stable and the parallelism was good.The product process was reasonable and feasible.Suitable for industrial production.According to the "Chinese Pharmacopoeia 2005 Edition" and the requirements of new resource foods,the functional ingredients of this product were determined to be salidroside,crude polysaccharides,cordycepin,and the corresponding quality standards were investigated according to the GB16740 national food safety standard health food.The product has a good linear relationship,The specificity,stability,precision,accuracy,repeatability,and intermediate precision are good,indicating that the measurement method is stable and feasible.It can be used as the methodology of Rhodiola pupa Cordyceps tablets,combined with the self-test results of pilot products Sensory requirements,physical and chemical indicators,microbiological indicators.The sample safety study showed that the maximum tolerated dose of 20 g/kg BW was orally administered without any adverse reactions;compared with the control group,the incidence of micronucleus of polychromatic erythrocytes and the incidence of erythrocyte sperm deformity were not obvious Sex difference(P>0.05).Immunofunctional studies have shown that long-term administration of Rhodiola rosea Cordyceps tablets has no significant effect on the weight,spleen index,and thymus index of mice.Compared with the solvent control(0g/kgBW),each control test group swallowed The cell index was significantly increased(P<0.05),and the high dose(2.70g/kgBW)significantly increased the swelling of the foot,the ability of the lymphocyte index to increase,and the hemolytic cell value of half of the mice(all P<0.05). |
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