Adaption And Clinical Initial Application Of The Chinese Vertion Of VEnous INsufficiency Epidemiological And Economic Study-Quality Of Life/Symptoms(VEINES-QOL/Sym) Questionnaire

Objective:1.To introduce the VEnous INsufficiency Epidemiological and Economic Study-Quality of Life/Symptoms(VEINES-QOL/Sym)questionnaire,we make a cultural adaption and assess the validity and reliability of the VEINES-QOL/Sym in patients with deep venous thrombosis.This study aims to form a newer,more reliable and more time-sensitive measurement instrument for the quality of life assessment of patients with deep venous thrombosis in China.2.We use the VEINES-QOL/Sym questionnaire to preliminary investigate the patients with deep venous thrombosis(DVT).And we want to understand the status of life quality of patients with deep venous thrombosis and to analyze the influencing factors,which can provide theoretical guidance for clinical workers in formulating the interventional strategies to improve the quality of life of patients with deep venous thrombosis.Methods:1.We introduce the VEnous INsufficiency Epidemiological and Economic Study-Quality of Life/Symptoms(VEINES-QOL/Sym)questionnaire into China,and then we complete the forward-translation,back-translation and cultural adaption for this questionnaire.Moreover,we verify the Chinese version questionnaire by the way of the psychological measurement of questionnaire which includes the test of reliability and validity(such as content consistency reliability,retest reliability,split-half reliability,structure validity,content validity and criterion-related validity)in 335 patients with deep vein thrombosis.Thus,we obtain the measuring tool of this study.2.Through methods of theory study,literature review and expert consultation,we determine the influencing factors and measuring instruments,including the Chinese-version VEINES-QOL/Sym questionnaire in Section1,MOS 36-item Short Form Health Survey questionnaire(SF-36)and demographic and disease data questionnaire In Section 2,we investigate 335 patients with deep vein thrombosis from 2 three-level hospitals in Nanchong city in Sichuan Province,which aim to verify the test of reliability and validity again and to analysis the status and the significant factors for the quality of life of patients with deep venous thrombosis,by the means of one-way ANOVA analysis of variance,Pearson correlation analysis and multiple linear regressions.Results:1.The results of item analysis in pilot study demonstrated that all 25 items had a good identify degree.And through principal component analysis with oblique rotation,we resulted in four factors explaining 69.88% of the variance.So,the four factors were named symptoms,physical functioning,role-physical and mental health respectively.The S-CVI of the questionnaire was 0.97,and the I-CVI of all items were 0.86~1.00 in the Chinese-version VEINES-QOL/Sym questionnaire.And the Cronbach's ?,Guttman split-half and test-retest coefficients were 0.930,0.792 and 0.929 respectively.Meanwhile,the criterion-related validity between the Chinese-version VEINES-QOL/Sym and the Chinese-version SF-36 was 0.816,which implied this questionnaire had good reliability and validity.2.The scores for patients with deep vein thrombosis in the quality of life,symptoms,physical functioning,role-physical and mental health were(49.98±6.64),(49.58±7.49),(50.01±8.19),(50.02±8.93)and(50.00±9.06),respectively.For DVT patients with different disease types,the peripheral DVT patients had got the highest scores of the quality of life.And the followed is the central type of patients.And the mixed type patients had got the lowest scores.3.Nonparametric test and one-way ANOVA analysis of variables found that different gender,age,occupation,work status,educational level,number of children,lifestyle,economic income,types of medical insurance and treatment stage for the scores of quality of life were different in patients with deep venous thrombosis,and the differences were statistically significant(P<0.05).4.Multiple linear regression results showed that the variables of treatment stages,culture degree,living with spouse/child together,the company staff,number of children and part-time work were entered the model,which accounted for 28.1% of the total variances.This means these six variables account for a total of 28.1% of the quality of life.Conclusions:1.After standard psychometric test,as a self-reported questionnaire,the Chinese-version VEINES-QOL/Sym questionnaire has good reliability and validity.So,it accords with psychometric indexes of evaluation results.The questionnaire is suitable for quality of life measurements in patients with deep vein thrombosis under the background of Chinese culture.Meanwhile,it can be applied in Chinese patients with deep vein thrombosis.And this study can provide a newer,more reliable and more timeliness evaluation instrument for Chinese patients with deep vein thrombosis quality of life.2.The variables of treatment stages,culture degree,living with spouse/ child together,the company staff,number of children and part-time work--work less than 40 hours a week were entered the model.The above results can be used to evaluate the quality of life of patients with deep venous thrombosis in clinical work,which can formulate targeted intervention programs to improve the quality of life in patients with deep vein thrombosis.