| Part one Evaluation of strong ion gap and other indicators on prognosis of severe pneumonia in childrenObjective: To investigate the value of strong ion gap(SIG),anion gap(AG),albumin(ALB),and the anionic gap corrected by albumin(ACAG)and lactate(LA)in evaluating the prognosis of severe pneumonia in children.Methods: Medical College from 2014 to 2017 were selected as study subjects.20 death patients and 159 survivors were analyzed respectively according to their prognosis.The data of Na+,K+,Cl-,HCO3-,Mg2+,Ca2+,p H,Pa CO2,P,ALB and LA were obtained from blood gas analysis and blood biochemistry.Based on this,ACAG was calculated by the Henderson-hasselbalach formula and SIG was calculated by the Stewart-Figge formula.Results: In 179 cases of severe pneumonia,there were 20 patients in the death group and 159 patients in the survival group.,There were significant differences in ACAG,ALB,SIG,and lactate levels between the two groups(P < 0.05).The area,sensitivity,and specificity under these ROC curves were analyzed.ACAG,ALB and SIG were statistically different(P <0.05),The area of the SIG was greater than ACAG and ALB,indicating that the use of SIG as a predictor of disease prognosis was better than ACAG and ALB in determining disease prognosis.Conclusions: SIG,ACAG,ALB and lactate have the guiding value in assessing the prognosis of children with severe pneumonia.Meanwhile,SIG has a greater guiding significance for the assessment of the prognosis of children with severe pneumonia.Part two The short-term effect and long-term prognosis of recombinant human interferon alpha-1b in the treatment of Infantile BronchiolitisObjective: To study the effect and long-term prognosis of recombinant human interferon alpha-1b in the treatment of infantile bronchiolitis with different routes of administration and different dosage.Methods: a total of 123 hospitalized children who met the diagnostic criteria of bronchiolitis in pediatrics of affiliated Hospital of North Sichuan Medical College were randomly divided into 4 groups,including 30 cases in control group(conventional symptomatic and supportive treatment)and the rest on the basis of routine treatment divide into intramuscular injection group 35 cases(given rh IFNα-1b intramuscular injection,each 1μg / kg,bid),low dose spray group 25 cases(given rh IFNα-1b atomization,each 1μg / kg,bid),33 cases of nebulized high dose group(atomized by rh IFNα-1b,2μg / kg each time,bid).All the 4 groups were given conventional symptomatic and supportive treatment.The situation was followed up by phone in 6 months to find out wheezing again in each group to evaluate the long-term prognosis.Results: There was significant difference in the time required for the disappearance of clinical symptoms and signs between intramuscular injection group,low and high dose groups of atomization and the control group(P<0.05).The time required for the disappearance of clinical symptoms and signs in the atomization group was less than that in the intramuscular injection group.The clinical symptoms and signs in the high dose group were shorter than those in the low dose group.The total effective rate of atomization group was higher than that of intramuscular injection group(P < 0.05).There was no significant difference in the total effective rate between the low dose group and the high dose group(P>0.05).four groups of children were followed up 6 months after discharge,the difference was not statistically significant(P>0.05).Conclusion: Recombinant human interferon α-1b has a certain curative effect on infant bronchiolitis,and atomization is a better way of administration,and has better efficacy and safety.High dose atomization can shorten the time of disappearance of symptoms in acute stage.The treatment of recombinant human interferon α-1b does not affect the long-term prognosis of bronchiolitis in infants. |
PDF Full Text Request