Analysis Of The Risk Factors For Portal Vein Thrombosis In Patients With Liver Cirrhosis And The Efficacy Of Anticoagulation Therapy

Objective:To explore a variety of risk factors for portal vein thrombosis in patients with cirrhosis.Analyze the effect of anticoagulant therapy on gastrointestinal hemorrhage in patients with liver cirrhosis and PVT.And by comparing the effect of thrombolysis before and after anticoagulant therapy,the efficacy of anticoagulant therapy was evaluated.Methods:This study collected 140 cases of cirrhosis patients from January 2014 to December 2016 in the First Affiliated Hospital of Anhui Medical University by retrospective method.Among them,there were 70 patients with cirrhosis and portal vein thrombosis(PVT).In addition,cirrhosis without portal vein thrombosis in 70 cases as a control group.The related clinical data of two groups were collected.The data of two groups were compared and analyzed.by using the single factor analysis and logistics regression model.The risk factors confirmed there is a correlation by univariate analysis and logistic regression analysis were identified as independent risk factors.For patients with cirrhosis and PVT treated with anticoagulant drugs,whether or not recurrent gastrointestinal bleeding was observed within 1 year to analyze whether anticoagulant therapy had an effect on gastrointestinal bleeding.And Ultrasound and CT examinations were performed to compare thrombus ablation after one year in the anticoagulation group and the non-anticoagulation group.Results:The results of history of endoscopic treatment,history of gastrointestinal bleeding,history of splenectomy,albumin value,hemoglobin value,Prothrombin time,platelet value and D-dimer were statistically significant between the two groups by single factor analysis.Multi-factor logistic regression analysis showed that there was Statistical significance between the results of history of splenectomy,hemoglobin value,platelet value and D-dimer.There was no significant difference in the incidence of gastrointestinal hemorrhage in the liver cirrhosis with PVT between anticoagulation group and the non-anticoagulation group.In the anticoagulation group,the thrombolysis was better than that of the non-anticoagulation group.Conclusion:The results of comprehensive univariate analysis and multi-factor logistic regression analysis show that the history of splenectomy,Reduced hemoglobin,thrombocytopenia and elevated D-dimer are independent risk factors of portal vein thrombosis.Clinically,patients with cirrhosis who have the above independent risk factors should be excluded from the complication of portal vein thrombosis,and make appropriate preventive treatment.Anticoagulant therapy has no significant effect on gastrointestinal bleeding in cirrhosis patients with PVT.Anticoagulant therapy may have a certain therapeutic effect on portal vein thrombosis.