Analysis On Clinical Characteristics Of Elderly Patients With Ulcerative Colitis

Objective:Ulcerative colitis（UC）is a non-specific inflammatory disease of the intestinal tract with unclear causes.The course of disease is long and protracted.It can be seen at any age.The incidence rate in Europe and the United States is high^[1].However,in recent years,as the incidence of UC has increased year by year and the ageing has intensified,more and more elderly patients have UC.This poses a serious challenge to clinical diagnosis and treatment..This study retrospectively analyzed the clinical features of elderly patients with ulcerative colitis.Methods:The detailed clinical data of 150 patients with UC admitted to our hospital from 2012 to 2018 were collected for retrospective analysis.According to the age segmentation standards which is proposed by the United Nations World Health Organization（WHO）and related literature^[2],patients were divided into older groups（≥60 years old）in 25 cases and young-middle age patients（<60 years old）125 example.The degree of illness,clinical manifestations,microscopic and pathological findings,extent of disease,and treatment of the two groups of patients were compared.Differences between groups were compared using thec2 test（Fisher exact probability method）and P<0.05 was considered statistically significant.Results:There were 25 elderly patients,accounting for 16.7%of the total number.For elderly patients,the lesions were more located at left hemicolon and rectum;And electrolyte disturbances were more common than those in young-middle age patients,P<0.05;The changes of coagulation function were obviously different from that of the control group,P<0.05.There were 12 cases（44%）with atypical hyperplasia in the elderly group,significantly higher than that in young-middle age patients（17.6%）,P<0.05;And inefficiencies of medical treatment （16%,4/25）were significantly higher than that of young-middle age patients（4%,5/125）,P<0.05.Erythrocyte sedimentation rate（CRP）,C-reactive protein（CRP）,and platelet（PLT）in elderly patients were increased to varying degrees and related to disease activity,but there was no significant difference between the two groups,P>0.05.There was no significant difference in the general clinical manifestation,endoscopic performance,extra-intestinal manifestations,and activity level of the elderly patients,P﹥0.05.Conclusion:There is only one peak of age for onset of UC,that is,40-50 years old,which is mostly male.The lesions of elderly UC patients were mainly left colon and rectum,and the degree of illness was lighter than that of young adults.The change of blood coagulation function was lighter than that ofyoung-middle age patients,but there was no significant difference in the Baron grade of the two groups.The pathology of elderly UC patients showed that dysplasia was significantly higher than that of young-middle age patients,and it was prone to canceration.Older UC patients are more prone to electrolyte disturbances than younger patients.Elderly UC patients have high inefficiency in medical treatment and many complications.Surgical treatment in elderly patients is effective and does not increase the risk of postoperative complications.