| Objectives The purpose of this study was to explore the effects of inhaled budesonide on the treatment of acute asthma attacks in children with asthma,and the changes in IL-13,IL-17 and IL-6 in peripheral blood and the significance of the treatment.Methods Selection in May 2016-May 2017 tangshan people’s hospital pediatric ward in the diagnosis of children with bronchial asthma treated 150 cases as the research object,among which 82 were male,female 68 cases,the ages of 6 and 14 years old,average age is(9.2±1.4).Conforms to the pediatric branch of Chinese medical association respiratory group "the Chinese journal of pediatrics editorial board of the child bronchial asthma diagnosis and prevention and cure guide(2016 edition)in diagnosis of children with mild and moderate asthma,all patients according to admission order were randomly divided into 3 groups,group treated with budesonide(BUD),meng LuSi,the treatment group(MK)and budesonide combined LuSi meng,the treatment group(BUD+MK group),each group of 50 people,in addition set of 50 cases clinic kindergarden children to healthy controls,male 26 patients,24 cases of female,age 6 to 14,7.5±3.2 years on average.The budesonide group(BUD group)was treated with budesonide(H20030410,astrazeneca)twice daily,inhaling 2ml each time and inhaling for 10 min.Menuster group(MK group)was used for treatment with montrast tablet(J20130047,Merck & co,LTD.),taking 5mg per day before bed for 2 weeks.Budesonide combined LuSi meng,the treatment group(group BUD+MK)with budesonide(H20030410,astrazeneca pharmaceutical companies)treatment,2 times a day,each time 2 ml,atomization inhalation inhalation 10 min,and on the basis of the use of meng LuSi special piece(J20130047,Merck pharmaceutical co,LTD.)treatment,take every night before going to bed,5 mg each time,2 weeks treatment.The healthy control group received no treatment and only received the same assessment as those in the treatment group.Inspection groups with symptom scores before and after the treatment,each group of children with lung function,application of enzyme-linked immunosorbent technique(enzyme linked immunosorbent assay,ELISA)to detect serum IL-13 groups of children,IL-17,the expression of IL-6 levels,and record of FVC,FEV1,PEF % value.Statistical analysis was performed using SPSS 19.0 software.Results 1 BUD+MK combination therapy was better than BUD alone.In the symptom scores of children after treatment,the scores after treatment in the BUD group(1.64±0.45)were significantly higher than those in the BUD+MK group(0.72±0.23 points)(P<0.05),indicating that the efficacy of the combination therapy was better than that of the individual medication.In terms of pulmonary function FVC,FEV1,and PEF% in children,BUD group after treatment(3.17±0.43 L,1.60±0.29 L,78.54±7.04L/s)and BUD+MK group(3.99±0.44 L,1.75±0.26)L,83.98±6.48L/s)was significantly higher in children than controls(2.69±0.30 L,1.42±0.37 L,65.11±7.26L/s)(P<0.05).However,the BVC group had significantly lower FVC,FEV1,and PEF% after treatment than the BUD+MK group(P<0.05),further indicating that the combination of BUD and MK was more effective than BUD alone.In addition,the levels of peripheral blood inflammatory cytokines in children were significantly higher than those in the BUD group(28.76±7.72,73.98±10.32,98.72±17.59 ng/L).After treatment,the BUD+MK group was(23.91±5.17,65.42±9.37,and 44.17±12.38 ng/L).The levels of IL-13,IL-17 and IL-6 in peripheral blood were significantly reduced in children with.2 BUD+MK combination therapy was better than MK alone.After the treatment of patients with symptom scores,MK group after treatment score(1.77 ± 0.51 points)was significantly higher than BUD + MK group(0.72 ± 0.23 points)(P <0.05),indicating that the efficacy of combination therapy is better than MK alone medication.In terms of FVC,FEV1,and PEF% in children with pulmonary function,the MK group after treatment(3.09±0.38 L,1.58±0.32 L,79.74±7.35L/s)and BUD+MK group(3.99±0.44 L,1.75±0.26)L,83.98±6.48L/s)was significantly higher in children than controls(2.69±0.30 L,1.42±0.37 L,65.11±7.26L/s)(P<0.05).However,the FVC,FEV1,and PEF% in the MK group after treatment were significantly lower than those in the BUD+MK group(P<0.05),further demonstrating that the combination of BUD and MK was more effective than MK alone.In addition,in patients with peripheral blood inflammatory cytokine levels after treatment,compared with MK group(29.34±8.06,75.16±10.86,102.21±18.06 ng/L),BUD+MK group(23.91±5.17,65.42±9.37,44.17±12.38 ng/L)The levels of IL-13,IL-17 and IL-6 in peripheral blood were significantly decreased in children with.Conclusions 1 The expression levels of IL-13,IL-6 and IL-17 were significantly increased in asthmatic acute episodes.2 After 2 weeks of treatment,the expression of peripheral blood IL-13,IL-6 and IL-17 in children with asthma attack was significantly reduced,and the effect was better than that of single drug.3 Application of budesonide combined with montrast can significantly improve the lung function of children with asthma attacks. |
