| Objective1. To study the relationship between serum triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio and acute coronary syndrome (ACS) and the severity of coronary artery lesions.2. To evaluate the clinical value of serum TG/HDL-C ratio in ACS prediction, diagnosis and disease evaluation.Methods1. In our heart line96cases of patients with ACS confirmed with coronary angiography were further divided into acute myocardial infarction (AMI) group and unstable angina pectoris (UAP) group according to the clinical, myocardial necrosis markers, electrocardiogram. Among them there were52cases of AMI group and44cases of UAP group. And we also chose50cases of negative patients confirmed with coronary angiography who lived into the hospital at the same period as a comparison group. After living in the hospital,we collected the general clinical data about all the research objects, examined serum TG, HDL-C, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) lipid levels, calculated TG/HDL-C ratio and analysised the correlation between serum TG/HDL-C ratio and ACS, the diagnosis value of ACS and the differences between the AMI and UAP.2. According to the results of coronary angiography,96cases of ACS patients can be divided into three subgroups:lesion in single coronary vessel (29cases), lesion in double coronary vessel (31cases), lesion in multiple coronary vessel (36cases), and we also used the Gensini score to evaluate coronary artery stenosis degree about patients and analysis the correlation between serum TG/HDL-C ratio and the severity of coronary artery lesions.Result1.Serum TG/HDL-C ratio relationship with ACS and value to the diagnosis of ACS(1) Serum TG/HDL-C ratio of ACS group is significantly higher than the control group [(1.92±0.68)vs.(1.89±1.05)vs.(1.35±0.82), P<0.01]. Between AMI and UAP, serum TG/HDL-C ratio have no statistical difference (P>0.05).(2) The multi-factor stepwise Logistic regression analysis between TG/HDL-C ratio and ACS showed that regression coefficient of TG/HDL-C ratio was1.543, P<0.001, odds ratio (OR) was2.964.TG/HDL-C ratio was associated with ACS.(3) The ROC curve of serum TG/HDL-C ratio analysis showed that the area under the curve of serum TG/HDL-C ratio is0.702,95%confidence interval from0.604to0.822, P<0.01. Serum TG/HDL-C ratio was valuable for ACS diagnosis. The best cut-off point was1.36, with a sensitivity of78.2%, specificity of54.3%.2.Correlation analysis between Serum TG/HDL-C ratio and the severity of coronary artery lesions of ACS(1) In ACS each lesion group, serum TG/HDL-C ratio was significantly higher than the control group:lesion in multiple coronary vessel group compared with control group:(2.19±1.14)vs.(1.35±0.82), P<0.001; lesion in double coronary vessel group compared with control group:(1.91±0.98)vs.(1.35±0.82), P<0.01; lesion in single coronary vessel group compared with control group:(1.62±0.55)vs.(1.35±0.82), P<0.05. Serum TG/HDL-C ratio of ACS group increased with the increase of coronary lesion count up, lesion in multiple coronary vessel group was significantly higher than that of lesion in single coronary vessel group (P<0.01) and lesion in double coronary vessel group (P<0.05), lesion in double coronary vessel group was significantly higher than that of lesion in single coronary vessel group (P<0.05).(2) Spearman correlation analysis between serum TG/HDL-C ratio of ACS group and Gensini score show that serum TG/HDL-C and Gensini score were significantly positively correlated (r=0.754), with statistical significance(P<0.05).(3) The multi-factor stepwise Logistic regression analysis between serum TG/HDL-C ratio of ACS group and Gensini score show that regression coefficient of TG/HDL-C ratio was0.623, P<0.05, OR was1.890. TG/HDL-C ratio has influence on Gensini score. Conclusion1. In ACS group, serum TG/HDL-C ratio was significantly higher than that of control group, but serum TG/HDL-C ratio has no statistical difference between AMI and UAP.2. Serum TG/HDL-C ratio is one of the risk factors of ACS.3. Serum TG/HDL-C ratio has certain diagnostic value on ACS.4. Serum TG/HDL-C ratio of ACS group was positively correlated with coronary lesion counts and Gensini score, increased with the increase of coronary lesion counts and Gensini score, which can indirectly reflect the severity of coronary artery lesions. |
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