Dynamic Observe The Effect Of Arsenic Trioxide In Children With Acute Promyelocytic Leukemia Coagulation Function

Objective:Patients with acute promyelocytic leukemia(APL)have significant coagulation abnormalities before and after treatment with arsenic trioxide(ATO),and severe cases can rapidly progress to disseminated intravascular coagulation(DIC),which is a major life threatening complication during induction therapy.This study aimed to identify the risk factors for DIC in patients with APL and to dynamically observe the effect of As2O3 on the coagulation function of children with APL.Methods:We collected basic characteristics,laboratory characteristics and coagulation index at various time points on admission of 28 children who were first diagnosed APL and treated with ATO at department of pediatric hematology in Shengjing Hospital from January 2012 to January 2018.We retrospectively analyzed the correlation between these factors and the occurrence of DIC,and the trend of dynamic changes in coagulation index with the passage of treatment time.Results: Of the 41 children identified,12(29.3%)developed DIC.There was no significant correlation between age,gender,blood routine index,fib,LDH and DIC in first diagnosed APL children(P <0.05).LDH>243U/L group had higher D-dimer before treatment(P=0.034).The high-risk group had higher PT before treatment and 3-4 days after treatment(P=0.004).The fib was lower in Hb> 90 g / L group before treatment(P = 0.027).Conclusion: There was no significant correlation between age,gender,blood routine index,Fib,LDH and DIC in newly diagnosed APL children.Before ATO induction therapy and 3-4 days after treatment are the key time point with significant abnormal blood coagulation of first diagnosed APL children.