Study On The Effect Of Shenlingbaizhu Powder On The Efficacy Of Patients With Acute Exacerbation Of COPD And Malnutrition(lung And Spleen Deficiency Syndrome)

Objective:To observe the effect of Shenlingbaizhu powder on the clinical efficacy of acute exacerbation of COPD with malnutrition,in order to use traditional Chinese medicine to help control the patient's condition in the acute exacerbation of COPD,alleviate the clinical symptoms and improve the quality of life,so that it can be used in clinical practice,and provide a certain value for the prevention and treatment of malnutrition with the combination of Chinese and Western medicine in the Prevention of COPD.The oretical basis and treatment perspective.Method:This study was a randomized,controlled study.The patients in the acute exacerbation period of COPD,which were dmitted from 01 months of 2016 to 01 months in the Department of respiration,Sichuan traditional Chinese medicine hospital,were admitted to the hospitalized patients with acute exacerbation,and the nutritional status of the patients was evaluated by Micronutrition assessment(MNA-SF scale)within 72 hours.Then 60 cases of acute exacerbation of COPD with malnutrition were randomly divided into two groups.The method was divided into 30 cases in the treatment group(enteral nutrition + Shen Ling Baizhu powder)and 30 cases in the control group(simple enteral nutrition).The two groups were all referred to the standard western medicine treatment plan for the diagnosis and treatment guidelines of chronic obstructive pulmonary disease(2013 Revised Edition).The improvement of nutritional status(albumin,hemoglobin,prealbumin,albumin,hemoglobin,prealbumin),the decreasing degree of inflammation(the total number of leukocytes,the percentage of neutrophils,C reactive protein),pulmonary ventilation function energy(oxygen partial pressure in arterial blood gas and two oxidation)were observed in the two groups before,5 and 10 days,respectively.Carbon partial pressure);before and after treatment,the two groups of CAT scores and TCM syndrome scores were compared.At the end of the treatment,the number of two groups of antibiotics used and the hospitalization and cost were observed and compared,and the safety of the two groups was monitored and evaluated,and the statistical analysis was carried out.Result:In the protein synthesis index,after treatment,the two groups of serum albumin and hemoglobin improved similar,compared with before treatment,the difference was statistically significant(P>0.05),the level of prealbumin was compared between the group,the treatment group was better than the control group(P<0.05).In the index of inflammation and blood gas,the two groups were improved after treatment.The improvement of leukocyte count,neutrophils percentage,C reactive protein,oxygen partial pressure and partial pressure of carbon dioxide in the treatment group were all better than those of the control group(P<0.05).In TCM syndrome score,the treatment group was better than the control group(P<0.05)in improving the symptoms of Na Dai,abdominal distention,loose stool,fatigue and fatigue.In the aspects of cough,expectoration,wheezing,chest tightness,lung dry and wet rale,fever and burnout,the symptom improvement of the treatment group and the control group was similar,there was no significant difference(P>0.05).In terms of efficacy,the clinical efficacy of the treatment group is better than that of the control group(P<0.05).In terms of quality of life score,the CAT scores of two groups were improved compared with those at admission,and the improvement rate of treatment group was more advantage than that of control group.In the time of use of antibiotics and the number of days in hospital,the treatment group could shorten the time of hospitalization compared with the control group,and there was no statistical difference between the two groups(P>0.05).From the aspect of drug safety,there was no obvious adverse drug reaction in the two groups after treatment,and the safety was good.Conclusion:The combined application of Shen Ling Baizhu powder in patients with acute exacerbation of COPD is better than that of pure western medicine.It can improve the clinical symptoms of the patients,improve the body's anoxia,reduce the retention of carbon dioxide,shorten the time of the use of antibiotics and the days of hospitalization,so as to improve the quality of life of the patients,and the curative effect is significant and safe and reliable.As for whether protein synthesis can be improved,the efficacy of this study is not clear enough,and further research is needed.