The Preparation Of Chouxueqing Capsule And Pharmacodynamics Research

The Chouxueqing capsule originates in clinical passes through the proven prescription,uses in treating the uarthritis,the curative effect is accurate.The prescription is composed of nine taste traditional Chinese medicines,for instance edible tulip,Corydalis tuber,Radix Stephaniae Tetrandrae.It has the refrigeration advantage to be wet,disappears effect of the rheumatism pain-rclicving.To further new medicine development research,according to its clinical practice,this topic have carried on the anti-uarthritis's related pharmacodynamics experiment,has confirmed the pharmacodynamics fu notion of Chouxueqing capsuleFirst,this article through the massive literature,summarized uarthritis's cause of disease,clinical research,treatment progress.Unifies with the prescription,elaborated with the Chinese medicine theory uarthritis's cause of disease,the pathogenesis and govern,has carried on the summary and the induction to each kind of traditional Chinese medicine's modern research.Second,the Pharmacodynamics research including the analgesia,the anti-inflammatory,the anti-hyperuricaemia tests.The analgesia experiment,uses the hot plate law and the acetic acid turns the body law,take Indomethacin as masculine comparison medicine,The high,middle and low monitoring team of Chouxueqing capsule and the blank control group are quite even have the remarkable difference(p<0.05),Indicated that the Chouxueqing capsule can obviously lengthen the hot stimulation ache threshold value,suppresses the acetic acid to turn the body response number of times obviously.The anti-inflammatory experiment,uses the mouse abdominal cavity injection histamine,the tail intravenous injection Evans blue method and the uric acid sodium crystallization injects the big mouse malleolus joint,establishes the big mouse acute malleolus arthritis model,observes the Chouxueqing capsule to be impervious and the detumescent function.Take Indomethacin as the masculine comparison medicine,The high,middle and low monitoring team of Chouxueqing capsule and the blank control group is quite even has the remarkable difference(p<0.05),Indicated that the Chouxueqing capsule has obviously is impervious the function,obviously suppresses the blood vessel permeability which the histamine causes to increase,suppresses the inflammation condition the further development,has the good anti-inflammatory detumescence function.The anti-hyperuricacmia tests,uses the Potassium Oxonate abdominal cavity injection to create the mouse hyperuricaemia,ia,other purine mellowly for masculine comparison medicine,The high,middle and low monitoring team of Chouxueqing capsule and the blank control group are quite even have the remarkable difference(p<0.05),The Chouxueqing capsule can reduce the blood uric acid obviously,causes the blood serum uric acid level to drop,meanwhile can suppress the xanzine oxidase level.The above experiment has con firmed the Chouxueqing capsule clinical care function effectively,has provided the technical support for its clinical practice.The compound prescription traditional Chinese medicine preparation ingredient is more complex,and it can function in many target spots.Moreover,its curative effect is various medicines blend the coordination the result.The role mechanism of Chouxueqing capsule possibly is with reduces hematuria acid water evenly,and suppress the xanzine oxidase actively and so on related,simultaneously reduced the inflammatory factor and the painful factor's content,played the good anti-inflammatroy and the analgesic effect.At present uses in treating uarthritis's traditional Chinese medicine preparation to be few,this experiment has laid pharmacodynamics foundation for the Chouxueqing capsule's new medicine development.