Distributio Of Tcm Syndromes In Children With Recurrent Respiratory Tract Infection And The Correlation Study Between Tcm Syndromes And Serum Immunoglobulin And Trace Elements

1.TCM syndrome investigation1.1 Objective:To study the distribution of TCM syndromes in children with recurrent respiratory tract infection and to explore the correlation between symptoms and syndromes,and to provide evidence for diagnosis and treatment of recurrent respiratory tract infection in children.1.2 Methods: The general situation,main symptoms and signs of 287 children with recurrent respiratory tract infection were collected and sorted by means of epidemiological survey questionnaire,and then the related database was established.At last,SPSS21.0 statistical software was used for frequency analysis,cluster analysis and various syndromes-the main symptom analysis.1.3 Results: Among 287 children with recurrent respiratory tract infection,150 were males,accounting for 52.3% of the total number,including 64 cases of acute infection stage,86 cases of non acute infection period,137 cases of female,accounting for 47.7%of total number,including 45 cases of acute infection period,92 cases of non acute infection period.The TCM syndromes of acute infection were exogenous cold syndrome,exogenous wind-heat syndrome,phlegm-dampness lung syndrome and phlegm-heat lung syndrome,respectively,21 cases,45 cases,18 cases and 25 cases,the corresponding percentage was 19.3%,41.3%,16.5% and 22.9% respectively.The TCM syndromes of non-acute infection period were 68 cases,22 cases and 30 cases And 33 cases,accounting for 38.2%,12.4%,16.9% and 18.5% respectively.1.4 Conclusion: Children with recurrent respiratory tract infection had the most external syndrome of wind heat syndrome and lung qi deficiency syndrome.The production status,feeding patterns,diet,antibiotic usage,past illness and parental smoking history were related to RRTI.2.Clinical research2.1 Objective: To study the TCM syndrome differentiation of children with recurrent respiratory tract infection,and serum immunoglobulin and trace elements were used as testing indicators to investigate the association between TCM syndromes and immunoglobulins and trace elements in children with recurrent respiratory infection,and to seek the possible basis for the objectification of TCM syndrome differentiation.2.2 Methods: Sixty-three children with recurrent respiratory tract infections that meet the criteria for diagnosis,inclusion,and exclusion of this study were selected for TCM syndrome differentiation,and serum immunoglobulins(Ig A,Ig G,Ig M)and trace elements(Ca,Zn,Cu,Fe,Mg)were measured.The immunoglobulin was determined by immunoturbidimetry.The trace elements were determined by atomic absorption spectrometry,and another 30 healthy children were selected as control group.The data obtained were analyzed by SPSS21.0 statistical software package.2.3 Results2.31 Relationship between TCM syndrome type of recurrent respiratory tract infection in children(RRTI)and immunoglobulin The level of immunoglobulin in the three syndromes of RRTI of the Lung-Spleen-Qi Deficiency Syndrome,Intestinal Heat Accumulation Syndrome,and Spleen Deficiency and Liver Syndrome were analyzed by one-way ANOVA.The result was the levels of Ig A and Ig G of the three syndromes were reduced to varying degrees compared with the control group,P<0.05,the difference was statistically significant;the Ig M levels of the three syndromes were compared with the control group,P>0.05,the difference was not statistically significant.However,the levels of Ig A,Ig G,and Ig M in the three syndromes were compared using the LSD method,P>0.05,and the difference was not statistically significant.2.32 Relationship between TCM syndrome type of recurrent respiratory tract infection in children(RRTI)and trace elements The levels of trace elements in the three types of syndromes,including complex-induced spleen-qi deficiency syndrome,gastrointestinal heat accumulation syndrome,and spleen deficiency and liver-wang syndrome,were analyzed by one-way analysis of variance and found that the levels of zinc,iron,and calcium in the three syndromes were lower than those in the control group.There were different degrees of reduction,P<0.05,the difference was statistically significant;the levels of magnesium and copper in the three syndromes were compared with the control group,P>0.05,and the difference was not statistically significant.However,the levels of zinc,iron,calcium,magnesium,and copper in the three syndromes were compared using the LSD method,P>0.05,and the difference was not statistically significant.2.33 Correlation analysis of serum immunoglobulin and trace elements in children with recurrent respiratory tract infection Pearson correlation analysis showed that there was no correlation between serum Cu,Ca,Mg,Fe and Ig A,Ig G,Ig M levels in the 63 retarded children(P>0.05),while the serum Zn concentration was positively correlated with the level of Ig A and Ig G(P<0.05).2.4 Conclusion1.The levels of immunoglobulin(Ig A,Ig G),trace elements(Zn,Fe,Ca)in three syndromes of complex sensitivities of lung and spleen qi deficiency syndrome,gastrointestinal heat syndrome and spleen deficiency liver syndrome were lower than those in the control group.2.The levels of immunoglobulins(Ig A,Ig G,Ig M)and trace elements(Zn,Fe,Ca,Mg,Cu)in the three syndromes of Fugan Deficiency of the Lung and Spleen-qi Deficiency Syndrome,Intestinal Heat Accumulation Syndrome,and Spleen Deficiency and Liver-wang Syndrome There was no statistically significant difference between the two groups.However,whether immunoglobulin and trace elements can serve as objective indicators of standardized syndrome types and the syndrome differentiation of TCM is not comprehensive enough,the specific conclusions need to be further studied and confirmed.3.The content of Zn in sepsis was correlated with the level of Ig A and Ig G,while the other trace elements had no correlation with immunoglobulin.Due to the shortage of samples and other factors,this conclusion still needs further study to confirm.