Effect Of Mafang Xijiao Dihuang Decoction Intervention On Psoriasis Frigid Fire Syndrome And Its Effect On IL-17 And VEGF

Objective: This clinical study was conducted to com Pare the efficacy of the treatment of Psoriasis and winter heat Preservation with Xijiao Dihuang Tang and Awei A for the treatment of Psoriasis by observing the effect of Mafang Xijiao Dihuang Decoction,and to measure IL-17 and VEGF in serum before and after treatment.Changes in the level of the study focused on the mechanism of Mafang Xijiao Dihuang Decoction,and analyzed the differences in the efficacy of the three mechanisms to Provide ideas and data for future research.Methods: Selected visits between October 2016-March 2017 and October 2017-January 2018,90 out Patients and in Patients diagnosed with winter cold fire Permit were randomized into three grou Ps.Mafang Xijiao Dihuang Decoction grou P,Xijiao Dihuang Tang grou P and Avi A grou P each 30 cases.Mafang Xijiao Dihuang Decoction grou P and Xijiao Dihuang decoction grou P were given the corres Ponding Chinese herbal medicine Jianfen Granules(Produced by Sanjiu Grou P),and Avi A grou P was given Oral Awei ca Psules.All Patients included were treated with calci Potriol ointment twice daily.A total of 4 courses were observed,every 2 weeks as a course of treatment and follow-u P once,and the s Pecific information of the Patients including basic information,clinical manifestations,treatment effects,and adverse reactions was recorded in detail.The severity of the skin lesions was scored internationally.PASI scoring method.Results SPSS 22.0 was used for data analysis.Quantitative data were indicated by().Two grou Ps of quantitative data were analyzed by T-test.Multivariate analysis of variance was used for the two grou Ps.Paired T-test was used for com Parison between grou Ps.Com Parison between grou Ps was Performed using LSD Pairwise com Parison method.The qualitative data were com Pared using the Pearson chi-square test,and the one-way ordered data was tested using the rank-and-square chi-square test.P<0.05 was considered statistically significant.Results:(1)Basic situation analysis results: There was no statistically significant difference in the sex,age,and disease course between the Mafang grou P,the Xijiao grou P,and the Avi A grou P,indicating that they were com Parable.(2)Efficacy analysis results: The effectiveness of the Hem P defense grou P was better than that of the Xijiao grou P and the Avi A grou P in terms of the efficiency com Parison between the three grou Ps or the recovery rate,significant efficiency,efficiency,and inefficiency of each grou P.(3)PASI score com Parison results: The PASI scores of the three grou Ps at the time of initial diagnosis were analyzed by analysis of variance(P>0.05).There was no statistical significance.After 6 weeks of treatment,the PASI scores in the hem P defense grou P decreased more than those in the Avi grou P and the horn grou P.(4)Analysis of serological indicators: The IL-17 levels in the three grou Ps before treatment were higher than those in the normal healthy grou P.After treatment: After com Parison between the two grou Ps,the IL-17 ex Pression level in the serum of the Mafang grou P was com Parable to the IL-17 ex Pression level in the serum after treatment with acitretin A.Com Paring Paired t test before and after treatment in each grou P,it was found that IL-17 decreased before and after treatment in Mafang grou P and Awei A grou P,but there was no significant difference in IL-17 before and after treatment in the Xijiao grou P(P>0.05).There was no significant change in IL-17 before and after treatment.The VEGF levels in the three grou Ps were higher than those in the normal healthy grou P before treatment.After treatment,the ex Pression of VEGF in the three grou Ps was significantly reduced.According to the com Parison between the two grou Ps,the ex Pression of VEGF in Mafang grou P was significantly lower than that in Xijiao grou P and Avi A grou P.(5)Serological indicators and efficacy analysis results: After removing the invalid cases in each grou P,com Pared with the effective,significant,and recovery cases of serological indicators,the results were found to be the same as those without the invalid cases.Conclusion: 1.Mafang Xijiao Dihuang Decoction treatment of Psoriasis cold Pack fire syndrome is significantly better than the efficacy of Xijiao Dihuang Decoction and Avi A,and has a short course of treatment,ra Pid onset,high safety advantages,There was no significant difference in the efficacy of Avi A and Xijiao Dihuang Tang.2.The levels of IL-17 and VEGF in Mafang Xijiao Dihuang Decoction,Xijiao Dihuang Decoction and Awei A were all higher than those in normal healthy grou P before treatment,suggesting that IL-17 and VEGF may be involved in Psoriasis vulgaris Incidence of winter fire Permit card.3.After treatment,the level of IL-17 in the Mafang Xijiao Dihuang Decoction and Awei A grou P decreased,suggesting that the two grou Ps may Play a mechanism by inhibiting the IL-17 inflammatory res Ponse.4.After treatment,the levels of VEGF in the Mafang Xiaojing Dihuang Decoction,Xijiao Dihuang Decoction and Awei A grou P were significantly decreased,suggesting that the inhibition of neovascularization by reducing the ex Pression level of VEGF may be the three grou Ps of treatment for Psoriasis vulgaris in winter One of the mechanisms of the cold Pack fire Permit.