Ginkgo Ketonic Ester Dropping Combined Levamlodipine Besylate Tablets For Clinical Observation For The Treatment Of Essential Hypertension Blood Stasis

Objective:By using Ginkgo ketonic ester dropping combined Levamlodipine besylate tablets for treatment of primary hypertension patients with blood stasis,observe Ginkgo ketonic ester dropping the signs and symptoms of patients with high blood pressure,blood stasis and blood rheology,the influence of Ginkgo ketonic ester dropping combined Levamlodipine besylate tablets and observation of efficacy and safety of the blood pressure.Research methods:Take Levamlodipine besylate tablets by collecting measures for treatment of patients with grade 1 hypertension TCM syndrome of blood stasis in 30 patients,observe the patient’s vital signs before the beginning of the experiment,testing the liver and kidney function,electrocardiogram,blood rheology indexes,and TCM syndrome score of blood stasis syndrome.Trial begins in the patients after Ginkgo ketonic ester dropping(40 mg each time,three times a day)and Levamlodipine besylate tablets(2.5mg once daily)therapy,monitoring during the patient’s vital signs,liver and kidney function and adverse reaction,the experiment observation process conforms to the standard clinical observation of patients to test the termination of the termination,and do the related record..Continuous observation after 12 weeks,blood rheology in patients with clinical observation and review of the review of TCM syndrome score of blood stasis syndrome,compare Ginkgo ketonic ester dropping combined Levamlodipine besylate tablets for treatment of blood stasis type of patients with essential hypertension(eh)clinical symptoms,signs,hemorheology and blood pressure changes before and after the test.Results:The symptom score of TCM blood stasis syndrome: in the aspect of improving the facial appearance of the main symptom of blood stasis syndrome,the score was significantly reduced before and after treatment(P < 0.05);Before and after treatment,the score was significantly reduced(P < 0.05)in the clinical symptoms of dizziness and headache in the improvement of blood stasis syndrome.Overall improvement of the symptoms of blood stasis patients with blood stasis was statistically significant before and after treatment.Blood pressure control: before and after treatment,the systolic blood pressure was significantly improved(P < 0.05),and the difference was statistically significant.The diastolic blood pressure was not significantly improved,and the difference was not statistically significant.The blood rheology indexes effect: reflect the aggregation of blood in blood rheology indexes(such as: blood sedimentation,erythrocyte aggregation index),before and after treatment index improved significantly(P < 0.05),statistically significant difference;Reflect the blood viscosity in blood rheology and deformation index(such as plasma viscosity,whole blood low shear reduction viscosity,whole blood high shear reductive viscosity,whole blood high shear relative index,whole blood low shear relative index,erythrocyte rigidity index,erythrocyte deformation index TK),before and after treatment index not seen obviously improved(P>0.05),there was no statistically significant difference.Blood pressure control: before and after treatment,the systolic blood pressure was significantly improved(P < 0.05),and the difference was statistically significant.The diastolic blood pressure was not significantly improved,and the difference was not statistically significant.Conclusions:1.Hypertension is a clinical common cardiovascular disease,hypertension patients have different degree of hemorheology in clinical abnormalities,concrete manifestation for the blood viscosity,concentration and the degree of deformation anomalies,and the abnormal hemorheology of also can further aggravate the occurrence of hypertension development;2.The doctor of traditional Chinese medicine thinks,the formation of blood stasis is the important pathogenesis of hypertension patients,blood stasis state is important in the development of hypertension has pathological link,is to improve for activating blood circulation and blood stasis type hypertension patients effective means in the stasis status;3.It can significantly improve the TCM clinical symptoms of blood stasis hypertension,which can effectively reduce the aggregation of blood and further improve blood stasis.In addition,the systolic blood pressure control of blood stasis patients treated by the combination of Levamlodipine besylate tablets is stable and has good clinical application value,which can be further studied and popularized.4.No obvious adverse reactions were observed before and after treatment.