Correlation Between The Severity Of Knee Osteoarthritis With Urinary Collagen Type ? C-Telopeptide And Urinary Cartilage Oligomeric Matrix Protein

ObjectiveTo observe the expression of urinary collagen type ? C-telopeptide(CTX-?)and cartilage oligomeric matrix protein(COMP)in patients with knee osteoarthritis(KOA),and their relevance to the severity of the disease were explored to evaluate the clinical significance of urinary CTX-? and COMP in KOA diagnosis and severity assessment.MethodsA total of 115 patients with KOA diagnosed in the Affilicated BenQ Hospital of Nanjing Medical University from August 2017 to March 2018 were selected as the KOA group.Depending on the K-L classification,they were classified from I to? grade.At the same time,50 healthy people from the Affilicated BenQ Hospital of Nanjing Medical University were randomly chosen as the control group.The urinary CTX-?I and COMP in all subjects were detected by enzyme linked immunosorbent assay(ELISA)and the results were analyzed and compared.ResultsLevels of urinary CTX-II and COMP in the KOA group were obviously higher than those in the control group(P<0.05).The levels of urinary CTX-? and COMP in the KOA group increased gradually with the increase of K-L grade,which were significantly different(P<0.05).The levels of urinary CTX-? and COMP in the KOA group were positively correlated with the severity of the disease(P<0.05).ConclusionKOA caused elevated levels of urinary CTX-II and COMP,which can be used as reference markers for the diagnosis and severity assessment of KOA.