Correlation Between Serum Levels Of S100? And MMP-13 And Coronary Heart Disease

BackgroundCoronary heart disease is the number one killer that seriously endangers human health.In Western countries,coronary heart disease is the leading cause of death.Although China is a low-risk country with coronary heart disease,the incidence and mortality of coronary heart disease have increased year by year in recent years.Become the main cause of death.In recent years,studies have shown that both S100? and MMP-13 are involved in the development and progression of atherosclerosis,but there are few studies on S100? and MMP-13 in cardiovascular diseases.The prevalence and mortality of coronary heart disease in China High,therefore,it is important to find more sensitive clinical test markers to provide a basis for early diagnosis and treatment of coronary heart disease and prevent further progression.This study was to investigate the relationship between S100? and MMP-13 and coronary heart disease.ObjectiveBy detecting the levels of S100? protein and MMP13,the correlation analysis between S100? protein and MMP13 levels and myocardial damage in patients with coronary heart disease was explored,which provided a reliable basis for early clinical diagnosis.Methods A total of 140 patients with coronary heart disease admitted to the First Affiliated Hospital of Xinxiang Medical College and the Second Affiliated Hospital from December 2017 to December 1818 were enrolled.All the subjects were diagnosed as coronary heart disease by coronary angiography and selected at Xinxiang Medical College.80 patients with non-coronary heart disease in a subsidiary hospital and the second affiliated hospital served as the control group,all with post-sternal pain,chest tightness and other discomfort,but coronary angiography excluded coronary heart disease,and ECG,cardiac ultrasound,blood glucose,blood lipids,homocysts For the detection of coronary heart disease,chronic heart failure,hyperlipidemia,hyperhomocysteinemia,hypertension,type 2 diabetes,after three measurements of blood pressure.The experimental group and the control group were collected 5 ml of fasting blood in the morning,separated by serum-70°,and the concentrations of S100? protein and MMP-13 in the experimental group and the control group were detected by enzyme-linked immunosorbent assay(ELISA).Statistics of the relevant auxiliary examinations at the time of admission(NT-proBNP,left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)),comorbidities(chronic heart failure,hyperlipidemia,hyper-half Cysteinemia,hypertension,type 2 diabetes),and correlation analysis,and analysis of its correlation with S100? and MMP-13.Results1.Comparison between coronary heart disease group and healthy control group The subjects were divided into 140 cases of coronary heart disease group and 80 cases of healthy control group.The levels of S100? protein and MMP-13 in coronary heart disease group were significantly higher than those in healthy control group.S100? protein was positively correlated with MMP-13(r=0.255,P=0.049).The difference was statistically significant(P< 0.05).2.Subgroup analysis of coronary heart disease There were 42 patients with acute coronary syndrome,96 patients with non-acute coronary syndrome,and 22 patients with ST-segment elevation myocardial infarction(STEMI)and unstable angina/non-ST segment.20 patients in the elevated myocardial infarction(UA/NSTEMI)group were compared with the control group and between the groups.S100? protein and MMP-13 in STEMI group,UA/NSTEMI group and non-acute coronary syndrome group were significantly higher than the control group,the difference was statistically significant(P<0.001);serum S100? protein and MMP-13 level in STEMI group Compared with the UA/NSTEMI group,the non-acute coronary syndrome group was significantly different from the STEMI group and the UA/NSTEMI group(P>0.05).3.Coronary heart disease combined with chronic heart failure A total of 60 patients with heart failure were divided into 3 groups according to cardiac function classification II~IV: 10 cases of NYHAII grade,30 cases of NYHA grade III,20 cases of NYHAIV grade,and serum S100? protein and MMP-13 of patients with cardiac function II~IV.The level of 13 was significantly higher than that of the control group,the difference was statistically significant(P<0.05),and the level of S100? protein was positively correlated with NT-proBNP(r=0.279,P=0.016),and the level of MMP-13 was significantly positive with NT-proBNP.Correlation(r=0.311,P=0.029).The left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)of heart failure group and healthy control group were measured by echocardiography.It was found that S100? and MMP-13 levels were significantly positively correlated with LVEDD in patients with different cardiac function grading(r =0.275,P=0.021),S100? protein and MMP-13 levels were significantly negatively correlated with LVEF(r=0.401,P=0.015),and the difference was statistically significant(P<0.05).It is suggested that the levels of S100? and MMP-13 can reflect the cardiac function of patients with coronary heart disease,which may have important reference significance for evaluating the severity of cardiac function.4.Blood lipids in patients with coronary heart disease A total of 52 patients,including 21 patients with hypertriglyceridemia,14 patients with hypercholesterolemia,and 17 patients with mixed hyperlipidemia.Serum levels of S100? and MMP-13 in patients with hyperlipidemia were significantly higher than those in the control group(P<0.05).Hypercholesterolemia group,hypertriglyceridemia group,mixed hyperlipidemia group There was no significant difference between the two groups(P<0.05).5.Homocysteine in patients with coronary heart disease A total of 28 patients,serum S100? and MMP-13 levels in the high homocysteine group were significantly higher than the control group,the difference was statistically significant(P<0.05);There was no significant difference between the high homocysteine group and the normal homocysteine group(P>0.05).6.Blood pressure in patients with coronary heart disease In the coronary heart disease group,there were 78 patients with normal blood pressure and 62 patients with hypertension.Among them,27 patients were in the hypertension group 1 group,23 patients in the hypertension group 2 group,and 12 patients in the hypertension group 3 group according to the hypertension classification criteria.The levels of serum S100? and MMP-13 in patients with normal blood pressure and hypertension were significantly higher in the coronary heart disease group than in the control group(P<0.05).In the coronary heart disease group,the normal blood pressure group and the hypertension group 1 group.There was no significant difference between the hypertension group 2 and the hypertension group 3(P>0.05).7.Blood sugar status in patients with coronary heart disease 46 patients with type 2 diabetes mellitus,serum S100? and MMP-13 levels were significantly higher in the group than in the control group,the difference was statistically significant(P<0.05);combined type 2 diabetes group and non-type 2 diabetes group The difference was not statistically significant(P>0.05).Conclusions1.The levels of serum S100? protein and MMP-13 in patients with coronary heart disease were significantly increased,and the degree of elevation increased with the severity of cardiac function classification.2.S100? protein and MMP-13 levels were negatively correlated with left ventricular ejection fraction(LVEF),and smoking,NT-proBNP,left ventricular end-diastolic diameter(LVEDD),homocysteine,blood lipids,blood pressure,blood glucose Both are positively correlated.