Clinical Study On The Relationship Between Hematocrit And Coronary Heart Disease With Qi Deficiency And Blood Stasis Syndrome

Objectives:To observe the hematocrit level of patients with coronary heart disease caused by qi deficiency and blood stasis syndrome,and to explore the correlation between hematocrit and qi deficiency and blood stasis syndrome.Methods:From March 2018 to December 2018,the patients admitted to the Department of Cardiology of Nanjing Chinese Medicine Hospital affiliated to Nanjing University of Traditional Chinese Medicine were enrolled in the hospital and outpatient clinic.120 patients with coronary heart disease diagnosed as coronary heart disease were enrolled as coronary heart disease group.According to the criteria of TCM syndrome differentiation,the patients were divided into two groups:qi deficiency and blood stasis syndrome and non-qi deficiency and blood stasis syndrome coronary heart disease group,60 cases in each group.According to the clinical classification criteria of coronary heart disease,the two groups were divided into two subgroups:chronic coronary artery disease group and acute coronary syndrome group,30 cases in each subgroup.70 patients with coronary heart disease who underwent coronary CTA examination in the same period of time were included as control group(including coronary atherosclerosis,myocardial bridge,valvular heart disease,pulmonary heart disease).,arrhythmia,etc.).According to the criteria of TCM syndrome differentiation,the control group was divided into two groups:qi deficiency and blood stasis syndrome control group and non-qi deficiency blood stasis syndrome control group,35 cases in each group.All subjects recorded clinical data in detail,including basic information such as name,gender,age,height,weight,etc.Personal history including history of smoking,past medical history including history of type 2 diabetes,history of hypertension,and family history Etc.The results include triglycerides,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,total cholesterol,red blood cell count,hemoglobin,and hematocrit.TCM syndromes include major symptoms,secondary diseases,tongue coating,pulse,etc.Registered in the case information collection form.(See Exhibit 1)Statistical analysis was performed using SPSS software for all clinical data.The differences in hematocrit and other indicators between the experimental group and the control group were observed,and multivariate logistic regression analysis was used to explore the risk factors of Qi deficiency and blood stasis syndrome.Results:1.After comparing the clinical data of qi deficiency and blood stasis syndrome and qi deficiency and blood stasis syndrome control group,the smoking history,DM history,age,low density lipoprotein cholesterol and triglyceride levels in qi deficiency and blood stasis syndrome were found.Both were higher than the control group of Qi deficiency and blood stasis syndrome,and the difference was statistically significant(P<0.05).Among them,the smoking history,age,and low-densi'ty lipoprotein cholesterol levels of the former were significantly higher than the latter(P<0.01).The high-density lipoprotein cholesterol,red blood cell count,hemoglobin and hematocrit levels in the qi deficiency and blood stasis syndrome group were significantly lower than those in the qi deficiency and blood stasis syndrome control group(P<0.01).2.In the qi deficiency and blood stasis syndrome,the red blood cell count and hematocrit in the chronic coronary artery disease group were lower than those in the acute coronary syndrome group,and the difference was statistically significant(P<0.05).The former has a significantly lower hematocrit than the acute coronary syndrome group.(P<0.01).3.After comparing the clinical data of the non-qi deficiency and blood stasis syndrome group and the non-qi deficiency and blood stasis syndrome control group,the history of hypertension,age,low density lipoprotein cholesterol and triglyceride in non-qi deficiency and blood stasis syndrome coronary heart disease group were found.The total cholesterol was higher than that of the non-qi deficiency and blood stasis syndrome control group,and the difference was statistically significant(P<0.05).Among them,the former age,low-density lipoprotein cholesterol and total cholesterol were significantly higher than the latter(P<0.01).The hematocrit of the non-qi deficiency and blood stasis syndrome group was lower than that of the non-qi deficiency and blood stasis syndrome control group(P<0.05).The red blood cell count of the former was significantly lower than the latter(P<0.01).4.In the non-qi deficiency and blood stasis syndrome,the red blood cell count,hemoglobin and hematocrit in the chronic coronary artery disease group were lower than those in the acute coronary syndrome group(P<0.05).Among them,the former's hematocrit was significantly lower than the latter(P<0.01).5.After comparing the clinical data of qi defi ciency and blood stasis syndrome and non-qi deficiency and blood stasis syndrome in coronary heart disease group,it is found that the history of hypertension and type A personality of qi deficiency and blood stasis syndrome coronary heart disease group is higher than non-qi deficiency and blood stasis syndrome.In the coronary heart disease group,the difference was statistically significant(P<0.05).Among them,the number of type A personality of the former was significantly higher than that of the latter(P<0.01).The red blood cell count,hemoglobin and hematocrit of the former were lower than the latter,and the difference was statistically significant(P<0.05).The hemoglobin and hematocrit of the former were significantly lower than the latter(P<0.01).6.The statistically significant difference between the qi deficiency and blood stasis syndrome coronary heart disease group and the non-qi deficiency and blood stasis syndrome coronary heart disease group was analyzed by multivariate logistic regression analysis.The results showed that type A personality,total red blood cell count,hemoglobin and hematocrit.It is a risk factor for patients with coronary heart disease with qi deficiency and blood stasis syndrome.(P<0.05)7.ROC curve analysis of hematocrit:The area under the ROC curve of hematocrit for coronary heart disease was 0.338(95%CI:0.239-0.437,P=0.002).The hematocrit cut-off point was 3 1.50%,the sensitivity was 90.0%,and the specificity was 1 5%.Conclusion:1.Patients with coronary heart disease have lower hematocrit levels than patients with non-coronary heart disease.2.The decrease of hematocrit in patients with coronary heart disease is related to the syndrome of qi deficiency and blood stasis in Chinese medicine.3.Reduced hematocrit is significantly associated with coronary heart disease with qi deficiency and blood stasis syndrome4.The correlation and mechanism of hematocrit levels with different clinical types of coronary heart disease are not clear.