Effect Of Salvianolic Acids In Treatment Of Acute Cerebral Infarction(Syndrome Of Static Blood Blocking Collaterals) And Its Effect On Serology Of VEGF,bFGF And Ang-1

Objective: To observe the effect of Slvianolic Acids on patients with acute cerebral infarction(stagnation of blood stasis syndrome),analyze its effect on serum VEGF,bFGF,and Ang-1,and explore the effect of Slvianolic Acids on promoting angiogenesis,so as to provide theoretical basis for clinical treatment.Methods: Eighty patients who were enrolled in the department of encephalopathy,the first affiliated hospital of anhui university of traditional Chinese medicine,were willing to participate in this study and confirmed as acute cerebral infarction by CT and MRI scans were collected.According to the principle of random control,the patients were divided into treatment group and control group.The control group was treated with conventional western medicine treatment,the treatment group on the basis of the control group used Slvianolic Acids,0.13 g added into normal saline,intravenous drip once a day.The course of treatment was 2 weeks in two groups.Venous blood was taken before and 14 th day after treatment,enzyme-linked immunosorbent assay was used to measure serum levels of the VEGF,bFGF,and Ang-1.At the beginning(0 weeks)and the end of treatment,the TCM blood stasis syndrome integral scale was used to evaluate the changes of TCM syndromes of patients,the national institutes of health stroke scale(NIHSS)was used to evaluate the neurological defects of patients in each group,and the activity of daily living scale(ADL)was used to evaluate the activity of patients in each group,and analysis the relationship between serum VEGF,bFGF,Ang – 1 and acute cerebral infarction.Results: 1.clinical efficacy evaluation:After 2 weeks of treatment,the total effective rate of the treatment group was 95%,and the recovery-apparent rate was 67.5%,which was significantly higher than 87.5% and 47.5% of the control group,and the difference was statistically significant(P < 0.05).The results showed that the clinical effect of the treatment group was better than that of the control group.After 2 weeks of treatment,the TCM blood stasis syndrome integral value in the treatment group and the control group decreased,especially in the treatment group(P<0.01).Compare two groups after treatment,the scores of blood stasis syndrome in the treatment group decreased more significantly(P<0.05).After 2 weeks of treatment,the NIHSS scores in the treatment group and the control group decreased,especially in the treatment group(P<0.01).Compare two groups after treatment,the NIHSS scores in the treatment group decreased more significantly(P<0.05).After 2 weeks of treatment,the activity of daily living scale in the treatment group and the control group decreased,especially in the treatment group(P<0.01).Compare two groups after treatment,the activity of daily living scale in the treatment group decreased more significantly(P<0.05).2.clinical index evaluation:Before treatment,the serum levels of VEGF?bFGF and Ang-1 were positively correlated with the severity of neurological impairment in ACI patients(P < 0.05).After treatment,the increase of serum levels of VEGF?bFGF and Ang-1 was positively correlated with the recovery of ACI patients(P < 0.05).3.Correlation analysis: Before treatment,the levels of serum VEGF,bFGF and Ang-1 levels were positively correlated with the severity of neurological deficits in ACI patients(P<0.05).After treatment,the levels of serum VEGF,bFGF and Ang-1 were positively correlated with the degree of recovery of ACI patients(P<0.05).4.Safety index: In the course of treatment,all patients did not appear the main complaint,the vital signs were stable,routine examination(blood,urine,stool routine + occult blood,electrocardiogram,liver and kidney function,coagulation function)results did not find significant abnormalities.Conclusion: 1.The curative effect of Slvianolic Acids on the treatment of patients with acute cerebral infarction(syndrome of static blood blocking collaterals)is remarkable,which can improve the condition of neurological dysfunction,improve the daily living level of patients,improve the symptoms of bleeding stasis of patients.2.The serum levels of VEGF,bFGF and Ang-1 in ACI patients were positively correlated with the severity of the disease.The serum levels of VEGF,bFGF and Ang-1 in ACI patients were positively correlated with the degree of recovery after treatment.3.Salvianolic Acids can promote the production of vascular growth factor VEGF,bFGF and Ang-1.It may be one of the important mechanisms of Salvianolic Acids in the treatment of acute cerebral infarction by inducing angiogenesis and promoting the establishment of collateral circulation in infarcted area.