Analysis Of Curative Effect And Prognostic Factors Of 124 Cases Of T1-4N3M0 Stage Nasopharyngeal Carcinoma

Objective:To retrospectively analyze the therapeutic effects of 124 patients with T1-4N3M0 stage nasopharyngeal carcinoma,and analyze the effects of gender,age,T stage,treatment mode,chemotherapy course,cumulative dose of cisplatin on the prognosis of T1-4N3M0 stage nasopharyngeal carcinoma.Methods:A retrospective analysis of 124 patients with T1-4N3M0 stage nasopharyngeal carcinoma who had no distant metastasis at the head and neck radiotherapy department of Jiangxi Cancer Hospital.The clinical data of 124 patients were collected,including gender,age,T stage,treatment mode,and chemotherapy regimen.radiotherapy dose,induction chemotherapy,etc.Survival analysis was performed by Kaplan-Meier method and multivariate prognostic analysis was performed by COX regression model.Results:The median follow-up time was 61 months(3-109 months).The 5-year overall survival rate(OS)was 57.3%and the 5-year long-distance metastasis-free survival rate(DMFS)was 55.6%.the 5-year progression-free survival(PFS)was 48.4%,the5-year local recurrence-free survival rate(LRFS)was 97.6%,and the 5-year regional recurrence-free survival rate(RRFS)was 98.4%.Multivariate analysis showed that the cumulative dose of cisplatin greater than or equal to 200mg/m~2could be used as an independent prognostic factor for 5-year OS,5-year DMFS,and 5-year PFS.T-stage and induction chemotherapy cycle can also be used as independent prognostic factors for 5-year PFS..Induction chemotherapy greater than or equal to 2 courses can improve the survival of patients,gender,treatment mode has no statistical significance for guiding the prognosis.Conclusion:The main mode of treatment failure in patients with T1-4N3M0 stage nasopharyngeal carcinoma is distant metastasis.Age and T stage can indicate the prognosis of patients.The cumulative dose of cisplatin over 200mg/m~2is of great significance in improving the prognosis of patients.Induced chemotherapy over 2courses may improve the survival of patients.To improve the efficacy of T1-4N3M0nasopharyngeal carcinoma,it is necessary to further explore the relevant factors to guide the prognosis of T1-4N3M0 nasopharyngeal carcinoma.