Sampling Survey On The Correlation Between Urolithiasis And Bone Mineral Density In Rural Residents Of A County In Chenzhou

Objectives Through the investigation of urolithiasis and bone mineral density in rural residents of a county in Chenzhou,we can understand the correlation between the two,which may provide a basis for screening high-risk groups of urolithiasis.Methods A cluster sampling method was used to select 340 permanent residents from 8 natural villages in a county of our city.Questionnaires were conducted to investigate their living habits,the prevalence of urolithiasis by B-mode ultrasonography,the bone mineral density of lumbar spine and hip by dual-energy X-ray absorptiometry,blood biochemical and bone metabolic markers,and to analyze the correlation between the prevalence of urolithiasis and bone mineral density.Results(1)Among 340 villagers in 8 villages,33 cases were diagnosed by B-mode ultrasonography,with an prevalence of 9.71%.Among them,135were males,with a prevalence of 14.07%.205 were females,with a prevalence of 6.83%.The prevalence of male urolithiasis is less than that of female urolithiasis(χ~2=4.875,P=0.038).(2)The prevalence of premenopausal and postmenopausal urolithiasis was 3.45%and 8.16%respectively.There was no significant difference in the prevalence of premenopausal and postmenopausal urolithiasis(χ~2=1.453,P=0.228).The prevalence of urolithiasis was 14.00%in males younger than 50 years old and 14.12%in males older than 50 years old.There was no significant difference in the prevalence of urolithiasis(χ~2<0.001,P=0.985).(3)25-hydroxyvitamin D in urolithiasis group(33.46±11.14)was significantly higher than that in non-urolithiasis group(28.75±9.06)(P=0.006);There was no significant difference in serum alkaline phosphatase between urolithiasis group(77.67±19.81)and non-urolithiasis group(73.64±22.97)(P=0.334);There was no significant difference in the degradation products of collagen beta between urolithiasis group(0.43±0.15)and non-urolithiasis group(0.37±0.18)(P=0.057);There was no significant difference in N-terminal procollagen of type I between urolithiasis group(64.93±25.60)and non-urolithiasis group(56.77±24.91)(P=0.076).(4)Postmenopausal women and men over 50years of age:the prevalence of urolithiasis was 11.11%in normal bone group,13.08%in low bone density group and 6.25%in osteoporosis group.There was no significant difference in the prevalence of urolithiasis among the three groups(χ~2=2.340,P=0.31);Premenopausal women and men younger than50 years old:the bone density in peers within the scope of urolithiasis prevalence was 7.84%,bone density is lower than peers group urolithiasis prevalence rate of 16.67%,there was no significant difference between the two groups in the prevalence of urolithiasis(χ~2=0.578,P=0.45).(5)Regression analysis of risk factors for urolithiasis showed that25-hydroxyvitamin D was an independent risk factor for urolithiasis(OR=3.43,95%CI:1.31-9.00).25-hydroxyvitamin D in urolithiasis group(33.46±11.14)was significantly higher than that in non-urolithiasis group(28.75±9.06)(P=0.006).Conclusion(1)There is no significant correlation between urolithiasis and bone mineral density in rural residents of a county in Chenzhou.Patients with abnormal bone mineral density may not be at high risk of urolithiasis.(2)25-hydroxyvitamin D is an independent risk factor for urolithiasis.Increased 25-hydroxyvitamin D may increase the risk of urolithiasis.