The Relationship Of Serum Triglyceride To High Density Lipoprotein Cholesterol Ratio With Acute Myocardial Infarction

Objective:To evaluate the association of serum triglyceride to high density lipoprotein cholesterol ratio(TG/HDL-C)with acute nryocardial infarction(AMI)incident and short-term(28days)all-cause mortality in patients with AMI.Methods:The study contains a cross-sectional study and a cohort study.In the first part,1637 patients with AMI were assigned to the observation group and 2424 patients without CHD were recruited to the control group.The relationship between TG/HDL-C level and AMI was analyzed by logistic regression after Propensity Score Matching.In the second part,the cohort study enrolled 1246 patients with AMI.The effect of TG/HDL-C on short-time(28days)mortality after AMI were measured by multivariate Cox proportional hazard regression.Results:Firstly,the TG/HDL-C level in observation group was significantly higher than that in control group(1.43(1.02,2.20)VS 1.33(0.85,1.86),P<0.000).After Propensity Score Matching,logistic analysis was used.On a continuous scale,1 standard deviation increase of TG/HDL-C levels was associated with an adjusted OR(95%CI)of 1.22(1.13-1.32),1.23(1.14-1.32),1.23(1.04-1.47)for AMI in the total patients,male patients and female patients,respectively.On a categorical scale,fully adjusted OR for AMI were 1.84(1.43-2.38)for Q2(Q 1 as reference),1.45(1.12-1.86)for Q3?2.61(2.00-3.39)for Q4 in patients.Stratifying by gender showed that adjusted OR were 1.77(1.32-2.37)for Q2,1.45(1.08-1.93)for Q3,2.66(1.97-3.58)for Q4 in men.The equivalents in women were 2.54(1.39-4.67)for Q2,2.30(1.20-4.40)for Q3,for 5.15(2.61-10.16)Q4(p for trend<0.01).Secondly,1246 patients with AMI were included.A total of 55 patients died in 28 days.After univariate and multivariate cox survival analysis,there was no statistically significant in the general population(P>0.05).Conclusion:There was an independent positive correlation between TG/HDL-C level and the risk of acute myocardial infarction.There was no significant correlation between TG/HDL-C and 28-day all-cause mortality in patients with acute myocardial infarction.