Relationship Between Arteriosclerosis And Oxidized Low Density Lipoprotein Levels In Patients With Systemic Lupus Erythematosus

Systemic lupus erythematosus(SLE)is an autoimmune disease that involves multiple systems and organs and has a variety of autoantibodies.The risks of clinical cardiovascular disease(CVD)and sub-clinical atherosclerosis are increased in patients with SLE.Atherosclerosis has been considered as one of the most important causes of CVD in patients with SLE.Oxidative stress is one of the main pathogenesis of atherosclerosis.Oxidized low-density lipoprotein(OX-LDL)is a major serological marker reflecting the level of oxidative stress and playing an important role in the formation mechanism of atherosclerosis.The increasing of plasma OX-LDL level is closely related to atherosclerotic diseases.Previous studies have shown that OX-LDL /LDL ratio is associated with subclinical atherosclerosis in patients with SLE.This indicates that OX-LDL/LDL ratio plays a role in the formation of atherosclerotic plaques in patients with SLE.However,the relationship between OX-LDL and arteriosclerosis in patients with SLE has been rarely reported.Objective: In this study we analyzed clinical data and laboratory indexes of patients with SLE.Differences of OX-LDL expressed between arteriosclerosis group and non-arteriosclerosis group was compared in order to discuss whether OX-LDL was a risk factor for SLE complicated with arteriosclerosis,and to provide a new target for the prediction of arteriosclerosis in patients with SLE.Methods:The clinical data of patients with SLE admitted in our hospital from September 2018 to January 2019 were analyzed.They were divided into the arteriosclerosis group and non-arteriosclerosis group(25 cases in each group).The differences of general data,laboratory indicators between the two groups were compared to observe whether the indicators such as OX-LDL were risk factors for arteriosclerosis in patients with SLE.All datas were analysised by SPSS 21.0.Results:1.There was no significant difference in age,body mass index,disease course,SLEDAI score and glucocorticoid dosage between atherosclerosis group and non-atherosclerosis group(P>0.05).2.Homocysteine level [18.00(3.70)]umol/L in arteriosclerosis group was significantly higher than that [11.80(3.10)]umol/L in non-arteriosclerosis group(P<0.01).3.OX-LDL level [39.60(2.35)]U/ml in arteriosclerosis group was significantly higher than that [30.90(20.01)]U/ml in non-arteriosclerosis group(P<0.01).4.Increased high-sensitivity c-reactive protein(OR=1.424,P=0.04),H CY(OR=1.404,P=0.02),OX-LDL(OR=1.39,P=0.01)increased the risk of ath erosclerosis in patients with SLE.Conclusion: OX-LDL,HCY and hs-CRP were risk factors for SLE with atherosclerosis.And they would be used as a important index to predict the risk of arteriosclerosis in patients with SLE.