Correlation Between Depression Symptoms And Cognitive Function And Abnormal Lipid Metabolism In Psychiatric Medical Staff

Objectives To investigate the status of depressive symptoms,cognitive function and abnormal lipid metabolism in psychiatric medical staff,and to explore the relationship between cognitive function of depressive symptoms and abnormal lipid metabolism and its influencing factors.Methods A total of 438 psychiatric medical staff were enrolled in psychiatric hospital between January 2018 and November 2017.The general demographic information were assessed by the self-compiled scale.Depressive symptoms were assessed by the Self-rating Depression Scale(SDS).Cognitive function were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Serum Total Cholesterol(TC),Triglyceride(TG),Low Density Lipoprotein Cholesterol(LDL-C)and High Density Lipoprotein Cholesterol(HDL-C)were detected.In this study,More then50 points in psychiatric medical staff will be defined as depressive group,and SDS<50will be defined as non-depressive group,comparing the differences of population,cognitive function and lipid metabolism between the two groups.To compare differences between cognitive function and depressive symptoms in normal and abnormal groups of lipid metabolism,and to further analyze the relationship between cognitive function and lipid metabolism in the depression group of psychiatric medical staff.Results 1 The detection rate of depressive symptoms of psychiatric medical staff was13.47%.2 The RBANS of psychiatric medical staff were(85.71±13.13),with a median value of 84.5 as compared to 43.38% lower than the median value.3 The abnormal rate of total cholesterol(TC≥5.2)was 37.44%.The abnormal rate of triglyceride(TG≥1.7)was 32.42%.The abnormal rate of low density lipoprotein cholesterol(LDL-C≥3.4)was21.49%.The abnormal rate of high density lipoprotein cholesterol(HDL-C<1.0)was3.9%.4 There was no significant difference between the depressive symptoms group and the non-depressive symptoms group in gender,education background,BMI,whether drinking,smoking,title and position(P>0.05).The age difference was statistically significant(P<0.05).5 The difference between the depression symptom group and the non-depression symptom group in immediate memory,visual span,attention function,delayed memory and RBANS total score was significant(P<0.05).6 There was no statistically significant difference in TC,TG,LDL-C,and HDL-C between the depressive symptoms group and the non-depressive symptoms group(P>0.05).7 Immediate memory and delayed memory scores in the TC metabolic abnormality group were significantly lower than those in the normal group(P<0.05).The immediate memory and delayed memory of the LDL-C metabolic abnormality group were significantly lower than those of the normal group(P<0.05).8 SDS score of the TG metabolic abnormality group was significantly higher than that of the TG metabolic normality group(P<0.05).9There was a significant negative correlation between SDS level and immediate memory in RBANS(r=-0.124,P=0.009),and SDS level was significantly negatively correlated with delayed memory in RBANS(r=-0.136,P=0.004);SDS level was significantly negatively correlated with RBANS total score(r=-0.137,P=0.004)in psychiatric medical staff.10 There was a significant negative correlation between TG metabolism level and attention function score in the depressive symptoms group(r=-0.317,P=0.014).11 The results of multivariate stepwise regression analysis showed that education,age,SDS standard score,BMI had predictive effect on cognitive function.Age had predictive effect on TC.BMI,sex,age and whether smoking had predictive effect on TG.BMI,whether smoking had predictive effect on HDL-C.Gender had predictive effect on LDL-C.Conclusions 1 Psychiatric medical staff with depressive symptoms have cognitive impairment,which is manifested in immediate memory,visual span,attention function,delayed memory and cognitive function decline.2 The higher the TG level of psychiatric medical staff with depressive symptom,the worse the attention function.It suggest that serum TG may be a factor affecting cognitive impairment.3 The abnormal metabolism of TC,TG and LDL-C may affect cognitive function.Figure6;Table7;Reference 213...