Relationship Between Serum 25-hydroxyvitamin D3 And Thyroid Function In Patients With Thyroid Autoantibodies And Hashimoto's Thyroiditis

Objective:To study the relationship between serum 25-hydroxyvitamin D3[25-?OH?D3]and thyroid autoantibodies,and the relationship between thyroid function and Hashimoto's thyroiditis?HT?in different stages.Methods:According to the exclusion criteria,the appropriate inclusions were selected,and the general data such as gender and age of the included persons were recorded.All the participants were tested for serum 25?OH?D₃ and free triiodothyronine?FT3?,free thyroxine?FT4?,Thyroid stimulating hormone?TSH?,thyroid peroxidase antibody?A-TPO?,thyroglobulin antibody?A-TG?levels.Comparison of serum thyroid autoantibody levels and positive rates in different 25?OH?D₃ nutritional status;Binary logistic regression analysis was used to study the relationship between the lack of25?OH?D₃ in serum and the positive expression of thyroid autoantibodies.According to the thyroid function status,the patients diagnosed with HT were divided into different progression stages,then,the relationship between serum 25?OH?D₃ levels and different25?OH?D₃ nutritional status at different stages of progression was compared with thyroid function status in patients with different advanced stages of HT.Results:Finally,501 researchers were included,including 428 women?85.4%?and 73 men?14.6%?.The level of 25?OH?D₃ in male serum was significantly higher than that in female serum?P<0.05?.The distribution of 25?OH?D₃ in different gender groups was different?P<0.05?;There was no significant difference in serum A-TPO levels between different25?OH?D₃ nutritional status groups?P>0.05?,and serum A-TG levels were statistically significant?P<0.05?;The positive rate of A-TG and the simultaneous positive rate of A-TPO and A-TG in different 25?OH?D₃ nutritional status groups were statistically significant?P<0.05?,however,there was no significant difference in the positive rate of A-TPO between different 25?OH?D₃ nutritional status groups and the difference between A-TPO and/or A-TG?P>0.05?;With the decrease of 25?OH?D₃ nutritional status,the positive rate of A-TG increased gradually?P<0.05?,and the positive rate of A-TPO and A-TG also increased gradually?P<0.05?.Serum 25?OH?D₃ levels were lower in the A-TG positive group than in the A-TG negative group,and the A-TPO and/or A-TG positive groups were lower than the antibody negative group,and,the levels were lower in the A-TPO and A-TG positive groups than in the non-simultaneous positive groups,and the differences were statistically significant?P<0.05?.Binary logistic regression analysis showed that increased serum 25?OH?D₃ levels reduced the likelihood of A-TPO positive,A-TG positive,A-TPO and/or A-TG positive?OR values are 0.972,0.964,0.962?,and,compared with serum 25?OH?D₃ level greater than or equal to 50 nmol/L,less than 50 nmol/L may increase the risk of A-TPO and or A-TG positive?OR value is2.514?;Gamma correlation analysis of thyroid function status in patients with different25?OH?D₃ nutritional status and different stages of Hashimoto's thyroiditis showed that with the nutritional status of 25?OH?D₃ decreases,the thyroid function status of HT patients tends to be hypothyroidism.Conclusion:Low level of 25?OH?D₃ is associated with positive thyroid autoantibodies.The decrease of 25?OH?D₃ level is associated with hypothyroidism in patients with Hashimoto's thyroiditis.