Correlation Between Serum Lipid Level And Aortic Dissection

Objective:Complete medical records of patients diagnosed with aortic dissection in our hospital were collected,and relevant data were statistically analyzed to study the correlation between blood lipid level and aortic dissection,and to explore new prevention and treatment strategies for patients with aortic dissection.Methods:Patients diagnosed with aortic dissection from January 2012 to June 2018 were selected.Detailed original medical records were transferred from the medical record room and 60 patients who met the criteria were selected to be included in the study group.By the same method,40 patients with hypertension with similar general medical records(including age,gender and blood pressure,etc.)were selected from the physical examination center and hypertension ward of our hospital as the control group.The general case data and relevant experimental data of the study group and the control group were statistically processed to study the correlation between them and aortic dissection.Results:Aortic dissection(aortic dissection,AD)group,a total of 60 patients with male 41 cases(68.3%),19 cases(31.7%)of women,age range at the age of 18 to81,the average age was(53.50 + 16.17),there are 19 cases(31.7%),smoking history,has a history of drinking,14 cases(23.3%),4 cases(6.7%)has a history of diabetes,the average systolic blood pressure(147.23 + 15.55)mmHg,average diastolic blood pressure(85.55 + 13.57)mmHg;There were 26 male patients(65%)and 14 female patients(35%)in the hypertension group,ranging from 20 to 84 years old,with an average age of 57.23 15.57 years old,14 patients(35%)with a history of smoking,11 patients(27.5%)with a history of drinking,3 patients(7.5%)with a history of diabetes,with an average systolic blood pressure(150.0514.58)mmHg,and an average diastolic blood pressure(89.10 10.10)mmHg.There was no significant difference in the above general data between the AD group and the hypertension group(P>0.05).There were significant differences between the two groups in TC,ldl-c,hdl-c,ApoA1 and other laboratory indicators(P < 0.05).The results of Logistic multivariate regression analysis indicated that TC increase(OR=2.130,95% confidence interval: 1.005-4.512,P =0.048)was positively correl ated with aortic dissection,hdl-c increase(OR=0.032,95% confidence interval: 0.002-0.471,P =0.012)and ApoA1 increase(OR=0.017,95% confidence interval: 0.001-0.218,P =0.002)were negatively correlated with aortic dissection.There was no significant difference between type A AD and type B AD in Cre,TC,TG,hdl-c,ldl-c,ApoA1 and other indicators(P>0.05).Among the 60 patients with AD,39 had hyperlipidemia,with a prevalence of 65%.The prevalence of hyperlipidemia was 14.28% in 5 of 40 patients with hypertension.The prevalence of hyperlipidemia in AD group was higher than that in hypertension group,and the difference was statistically significant(P<0.05).Conclusion:Abnormal lipid metabolism may be present in most patients with dissection,especially those with hypertension.Active and effective control of blood pressure and scientific adjustment of blood lipids in patients with hypertension may effectively reduce the risk of aortic dissection.