Relevance Of Lifestyle,Genetic Factors And Endocrine Levels In 302 Patients With Polycystic Ovary Syndrome And Distribution Characteristics Of TCM Syndromes

Objective:To explore the related factors of polycystic ovary syndrome,in order to understand the possible risk factors and protective factors of PCOS,provide theoretical basis for clinical diagnosis and disease prevention and treatment of PCOS,and lay a foundation for the preliminary formulation of the relevant prevention and treatment program of PCOS.To explore the distribution of TCM syndromes in PCOS patients and the risk factors and protective factors of TCM syndromes,so as to provide reliable basis for TCM clinical differentiation and treatment and guide the prevention of PCOS and clinical medication.Method:From September 2017 to February 2019,302 patients diagnosed as PCOS in gynecological outpatient clinic of Affiliated Hospital of Chengdu University of Traditional Chinese Medicine were selected as case group,and 300 healthy women with normal menstruation at the same age were selected as control group.The information of the two groups was collected,including general information,lifestyle,family genetic history,thyroid function,insulin function and four diagnostic methods of traditional Chinese medicine.Frequency analysis was used to explore the distribution of TCM syndromes,Chi-square test was used for univariate analysis and binary logistic regression was used for multivariate analysis to analyze the risk factors of PCOS.Results:The preliminary findings of this study are as follows:1.Univariate analysis of polycystic ovary syndrome suggested that Age,insulin resistance,thyroid function,sugary drinks,cured foods,spicy diet,raw and cold diet,light diet,length of sleep,exercise,mood,family history of obesity and other factors are related to PCOS(P<0.05).2.Multivariate analysis of polycystic ovary syndrome showed that the main risk factors of polycystic ovary syndrome were BMI,insulin resistance,thyroid dysfunction,salted diet,length of sleep and mood..Exercise and light diet are protective factors for PCOS.3.Univariate analysis of TCM syndromes showed that emotion was related to kidney deficiency,liver depression and spleen deficiency.BMI was related to spleen deficiency,phlegm-dampness and kidney deficiency.Family history of PCOS is related to spleen deficiency syndrome4.Multivariate Analysis of TCM Syndrome Types showed that greasy diet and abnormal mood were important risk factors for kidney deficiency syndrome;abnormal mood and sleep disorder were the main risk factors for liver depression syndrome;raw or cold diet,overweight or obesity were the main risk factors for spleen deficiency syndrome;and beverage,overweight or obesity were the main risk factors for phlegm-dampness syndrome.5.Among 302 cases of polycystic ovary syndrome studied,the most common TCM syndromes were spleen-kidney deficiency,liver depression,phlegm-dampness block in 45 cases(14.90%),kidney deficiency and liver depression in 43 cases(14.24%)and spleen-kidney deficiency,phlegm-dampness block in 36 cases(11.92%).The single syndrome of kidney deficiency occurred most frequently,286 cases(94.7%)followed by liver depression in 196 cases(64.90%),phlegm-dampness block in 181 cases(59.93%)and spleen deficiency in 175 cases(57.95%).Conclusion:1.There are many risk factors in patients with polycystic ovary syndrome,mainly for lifestyle.Health education for PCOS patients should be strengthened and healthy lifestyle should be advocated.2.The main TCM syndromes of patients with polycystic ovary syndrome are spleen and kidney deficiency,liver depression and phlegm dampness block,kidney deficiency and liver depression,spleen and kidney deficiency and phlegm dampness block,and kidney deficiency is the main single syndrome.Compound syndromes account for the vast majority.The disease is mainly caused by the mixture of deficiency and excess.There is a certain correlation between lifestyle and TCM syndromes.