Metaanalysis Of Sperm DNA Damage And Pregnancy Outcomes After In Vitro Fertilization

Objective:to systematically evaluate the relationship between sperm DNA damage and pregnancy outcomes In vitro fertilization-embryo transfer(IVF-ET).Method:Using the retrieval scheme that combines computer retrieval and manual retrieval,retrieval Embase,Cochrane Library,Pubmed,CNKI,WanFang Data,VIP,and Google academic database.At the same time,References and conference materials were retrieved.The retrieval period is from the establishment of the database until March2018.Two searchers independently screened the literature,extracted data and evaluated the quality according to the inclusion and exclusion criteria.Then they used RevMan5.3 software for meta-analysis using a fixed-effect model.Results:After screening,17 study cohorts were included with a total of 2405 cycles.Meta analysis results suggested that high sperm DNA damage would reduce the clinical pregnancy rate(OR=0.77,95%CI:0.62-0.97),reduce fertilization rate(OR=0,80,95%ci: 0.74-0.86),and decreased embryo optimization rate(OR=0.78,95%ci: 0.72-0.85)of IVF-ET.Conclusion:high sperm DNA damage is associated with an increased risk of assisted reproductive failure by in vitro fertilization.And the detection of sperm DNA damage degree is significant for predicting the outcome of IVF assisted reproduction.