Clinical Study Of Endoscopic Screening By Iodine Staining For High Risk Populations Of Early Esophageal Cancer And Precancerous Lesions

Objective: To evaluate the clinical diagnostic value of endoscopic screening by iodine staining on early esophageal cancer and precancerous lesions.Methods: Endoscopic iodine staining was performed in patients with high risk factors of esophageal cancer from April 2018 to July 2018.The esophageal mucosa was observed and recorded before and after taking iodine staining,and targeted biopsy was performed on the lesion to obtain histopathological results and make analysis.Results: The 203 patients were enrolled in study and found 25(12.3%)cases of esophageal lesions,including 19(9.3%)cases of esophagitis,2(1.0%)cases of low grade intraepithelial neoplasia,and 4(2.0%)cases of high grade intraepithelial neoplasia.The areas of light-stained and non-stained were mostly found in rough,erosive,reddish,concave and irregular esophageal mucosa under white light endoscopy.Endoscopy imaging of early esophageal cancer and precancerous lesions were mainly manifested as redness,roughness and irregular depression of mucosa under white light endoscopy.However,Endoscopy imaging of esophagitis were often showed as normal mucosa,roughness and erosion of mucosa.In this study,all of the early esophageal cancer lesions were found in the non-stained areas,and the pink signs of the mucosa were positive.Conclusion: The iodine staining can apply for screening early esophageal cancer and precancerous lesions in high risk populations.During endoscopic examination,the red,rough,and concave irregular mucosa,the light-stained and non-stained areas with iodine staining,and the pink sign positive sites should be targeted for biopsy,to improve the diagnosis of early esophageal cancer and precancerous lesions.