| Objective:To analyze the changes of serum cystatin C levels in patients with chronic heart failure(CHF)in different cardiac function grading,and to explore the correlation between serum cystatin C level and ventricular remodeling in chronic heart failure.Methods:291 patients with chronic heart failure diagnosed with chronic heart failure and aged over 60 years were enrolled in the Department of Cardiology Between January 2017 and January 2019,according to the New York Heart Association(NYHA)and 6-minute walking cardiac function grading method were graded into heart function level II,heart function level III,heart function level IV;according to Dereuxand Ganau criteria into ventricular remodeling group(VR)and non-ventricular remodeling Group(Non-VR),subjects with non-heart failure in the physical examination department and aged over 60 years old were selected as the control group;Collect general clinical information of patients,including age,gender,height,weight,smoking or not,blood pressure,hypertension,coronary heart disease,diabetes,anemia,etc.Collection of examination results of patients with albumin,blood glucose,triglyceride,cholesterol,high-density lipoprotein,low-density lipoprotein,serum creatinine,urea,etc.Blood was taken on an emptystomach the next morning,and the concentration of serum cystatin C(Cysstat C)was measured by anautomatic biochemical analyzer.Measurement of ventricular remodeling by Doppler color ultrasound,including Left ventricular end-diastolic dimension(LVEDd),Posterior Wall Thickness(PWT),Interventricular septal thickness(Interventricular septal)Thichness,IVST),End-Diastolic Volume(EDV),End-Systolic Volume(ESV),Left Ventricular ejection fraction(LVEF),etc.Left ventricular mass index(LVMI)and relative wall thickness(RWT)were calculated from the above indicators.The measured datawere analyzed by SPSS 21 statistical software,and the P value was determined.The statistical results werestatistically significant at P<0.05.Results:(1)The CHF test group and the control group were statistically analyzed on the basic information such as age,body mass index(BMI),systolic blood pressure,diastolic blood pressure,heart rate,smokingor not,gender,hypertension,coronary heart disease,diabetes,and anemia.The results showed nosignificant difference(P>0.05);VR and Non-VR were compared in the basic data,there was no significantdifference in systolic blood pressure,diastolic blood pressure,heart rate,BMI,smoking or not,diabetes,anemia(P>0.05),The difference was statistically significant in age,gender,hypertension,coronary heartdisease(P<0.05).(2)In the CHF test group and the control group,the indexes of albumin,glucose,triglyceride,cholesterol,high-density lipoprotein,low-density lipoprotein,serum creatinine and urea werestatistically analyzed.The results showed no significant difference.(P>0.05).Cys C was statisticallysignificant in multiple comparisons between groups(P<0.05);VR and Non-VR are compared inbiochemical projects.There was no significant difference in ALB,GLU,TC,TG,HDL,LDL,Scr and Urea between the two groups(P>0.05).The difference of Cys C was statistically significant between thetwo groups(P<0.05).(3)Binary logistic regression of chronic heart failure with ventricular remodeling,Corrected the effects of age,gender,hypertension,and coronary heart disease on CHF ventricularremodeling in the elderly.when the Cys C level increased by one unit,elderly patients with chronic heartfailure The risk of ventricular remodeling increased by 0.952 times.(4)Cys C and ventricular remodelingand other indicators for correlation analysis.The results showed that Cys C was correlated with LVEDd,PWT,IVST,LVMI,EDV,ESV,RWT,EF(r,0.535,0.425,0.342,0.565,0.485,0.528,-0.399,-0.618,respectively,P<0.001).Conclusion:Serum Cys C is associated with ventricular remodeling in elderly patients with chronic heartfailure.When Cys C levels are elevated,the risk of ventricular remodeling is increased in elderly patientswith chronic heart failure. |
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