Study On The Correlation Between TCM Syndromes Of Essential Hypertension And CfPWV And Carotid Atherosclerosis

Objective:Based on the analysis of the relationship between TCM syndromes of essential hypertension and carotid-femoral artery pulse wave velocity(cfPWV)and carotid atherosclerosis,this study provides clinical basis for the early prevention of cardiovascular diseases.Method:A retrospective approach was conducted to select 120 patients with essential hypertension who were hospitalized or visited out-patient clinics in our hospital and to classify them according to TCM syndrome differentiation.The general information of the selected patients,carotid-femoral pulse wave velocity(cfPWV)and carotid Doppler ultrasonography were collected,and the data were collated.The correlation between TCM syndrome differentiation and typing groups of hypertension was analyzed by SPSS25.0 statistical software.Result:1.The distribution ratio of TCM syndrome type in hypertension: 66cases(55.00%)of phlegm-dampness stagnation syndrome>28 cases(23.33%)of Yin-Deficiency and yang-hyperactivity syndrome>14 cases(11.67%)of Yin-Yang deficiency syndrome>12 cases(10.00%)of liver-fire hyperactivity syndrome.2.IMT and cfPWV in hypertension group 2 and above were significantlyhigher than those in hypertension group 1 With the increase of blood pressure level,IMT and cfPWV are significantly higher,and the trend test is significant.(P<0.01).3.The factors influencing cfPWV include age,blood pressure grading and duration of disease.4.The age,course of disease,cfPWV and IMT of hypertension patients with carotid plaque group were higher than those without carotid plaque group(P<0.05).5.cfPWV was positively correlated with the formation of cervical atheromatous plaque.6.Age distribution,Yin-Yang deficiency syndrome is larger than the other three syndromes,and there is a significant difference with hyperactivity of liver-fire syndrome.(P<0.05).History of hypertension,the distribution of TCM syndromes is as follows:Yin and Yang deficiency syndrome>Yin deficiency and Yang hyperactivity>phlegm dampness stagnation syndrome > liver-fire hyperactivity syndrome.7.Comparing the pulse wave velocity(PWV)and carotid intima-media thickness(IMT)of different syndrome types of hypertension,there were significant differences between hyperactivity of liver-fire syndrome and yin-deficiency-yang-hyperactivity syndrome,phlegm-dampness-stagnation syndrome and yin-yang deficiency syndrome(P<0.05).There was no significant difference between hyperactivity of yin-deficiency-yang syndrome and phlegm-dampness-stagnation syndrome and yin-yang deficiency syndrome(P>0.05).Hyperactivity of phlegm-dampness syndrome was compared with yin-deficiency-yang hyperactivity syndrome and yin-yang deficiency syndrome.There was no significant difference(P>0.05).Yin-yang deficiency syndrome had significant difference compared with liver-fire hyperactivity syndrome(P<0.05),and had no significant difference compared with Yin-deficiency-yang hyperactivity syndrome andphlegm-dampness stagnation syndrome(P>0.05).Conclusion:1.The distribution of TCM syndromes of hypertension is mainly phlegm-dampness stagnation syndrome.2.Atherosclerosis is positively correlated with age,blood pressure grading and duration of disease.3.There is a correlation between the TCM syndromes of hypertension and IMT and cfPWV.With the increase of patients' age and the prolongation of the course of disease,the development from positive to deficient syndrome is also gradually evolving.The pulse wave velocity of Yin-Yang deficiency group is the fastest,IMT thickness is the largest,and carotid plaque formation rate is the highest.The high-risk type of atherosclerosis is Yin-Yang deficiency syndrome,which should be paid attention to in clinical treatment in order to achieve early detection and intervention.