The Relationship Between AST To ALT Ratio And Metabolic Syndrome In Adolescents In Northeast China

Objective: To investigate the correlation between the aspartate aminotransferase and alanine aminotransferase(AST/ALT)ratio and the metabolic syndrome(Met S)in adolescents of northeast China.Methods: 935 students sampled by stratified cluster random sampling(491 boys and 444 girls,aged 11-16 years old)in Liaoyang City,Liaoning province between 2010-2011 were enrolled,who filled in the questionnaire,received physical examination with determination of biochemical indicators,and were followed up after 5 years.Metabolic syndrome(Met S)was diagnosed according to the criteria for adolescents and adults,respectively,set by International Diabetes union in 2007.Results: In the baseline study,the AST/ALT ratio showed significantly negative correlation with waist circumference(WC)and waist hip ratio(WHR),body mass index(BMI),diastolic blood pressure(DBP),uric acid,triglyceride(TG),fasting insulin(FINS),low density lipoprotein cholesterol(LDL-C)and homoeostasis model of insulin resistance(HOMA-IR)in adolescence,but a significant positive correlation with high density lipoprotein cholesterol(HDL-C)(correlation coefficient r =-0.44 ~ 0.07,P <0.05).Multivariate Logistic regression analysis showed that the Met S risk of group with the lowest AST/ALT ratio was 6.02 times(95%CI(1.93,18.76))of the group with the highest AST/ALT ratio.Central obesity is the Met S component that demonstrated closest correlation with reduced AST/ALT ratio(OR = 5.13,95%CI(2.83,9.28)).5 years later,all subjects(n = 93)who agreed with follow-up examination had reached adulthood(?18 years old).The group with the lowest AST/ALT ratio at baseline still showed higher trend of Met S risk(OR = 3.61,95%CI(0.38,34.21))and significantly higher risk of overweight / obesity(OR = 4.85,95%CI(1.54,15.30)after 5 years compared with groups with highest AST/ALT ratio.The AST/ALT ratio at baseline is significantly correlated with overweight / obesity 5 years later(OR = 4.85,95%CI(1.54,15.30)).Conclusion: The AST/ALT ratio of adolescents in northeast China is closely related to Met S and its components,and the AST/ALT ratio in adolescence has a good predictive effect on overweight / obesity in adulthood.