Clinical Characteristics And TCM Syndrome Analysis Of 91 Patients With Interstitial Lung Disease

Objective:Summarized and analysed the clinical characteristics and TCM syndrome characteristics of 91 patients with different types of interstitial lung disease(ILD).Methods: About 91 cases of ILD from February 2017 to December 2019 in the Department of respiratory and critical care medicine of the Fourth Clinical Medical College of Xinjiang Medical University.The general data,clinical manifestations,serological indicators(such as blood routine,procalcitonin,interleukin,ESR,tumor markers),pulmonary imaging examination,TCM syndromes and other clinical data were collected and summarized.Results:1.There were 91 ILD patients,44 male,47 female,aged 60-79 years,including 17 rheumatoid arthritis(RA),18 primary Sjogren's syndrome(pSS),12 interstitial pneumonia with autoimmune characteristics(IPAF),25 undifferentiated connective tissue disease(UCTD),19 antineutrophil cytoplasmic antibody associated vasculitis(AAV).2.Among the clinical symptoms and signs,cough(85.7%),expectoration(81.3%)and popping sound(80.2%)accounted for a high proportion.There were 22 cases of joint pain,13 / 16 cases of dry eyes / mouth,14 cases of skin damage,9cases of fever,9 cases of fatigue outside the lung.3.The expression of CA125 was different between UCTD-ILD and AAV with ILD(P=0.049),and CA724 was different between AAV with ILD and pSS ILD(P = 0.002).4.The blood gas analysis was completed in 79 cases,54 cases of hypoxemia,13 cases of type I respiratory failure and 1 case of type II respiratory failure.5.The CT manifestations of lung in different ILD patients are different:mainly grid shadow and honeycomb shadow,followed by interlobular septal thickening,ground glass shadow,sheet exudation shadow,nodular shadow,cord shadow,cystic change,bronchiectasis and consolidation shadow.6.The frequency of TCM syndrome types is as follows: 45 cases of qi deficiency and blood stasis,22 cases of phlegm and turbid lung obstruction,12 cases of lung and kidney qi deficiency,5 cases of dryness andpathogenic lung injury,7 cases of phlegm and heat stagnation,0 case of phlegm and blood stasis combination.Conclusion: 1.The majority of patients with ILD are elderly,with a high proportion of cough and expectoration.Extrapulmonary manifestations such as joint pain are common in RA,and dry eye / mouth are common in pSS.When patients with ILD have extrapulmonary symptoms,we should be alert to CTD-ILD.2.The expression of CA125 and CA724 in AAV-ILD was different from that in CTD-ILD,the tumor marker level of aav-ild was higher than that of ctd-ild.3.CT manifestations of lung in different ILD patients are different: mainly grid shadow and honeycomb shadow.4.Qi deficiency and blood stasis accounted for the largest proportion in different syndrome types.Dark red tongue with less moss and stringy pulse were more common in tongue pulse.It can be treated with Yiqi Huoxue.