| Objective: To study the clinical therapeutic effect of Shenqi Dihuang Decoction on chronic renal failure patients with deficiency of Qi and Yin.Methods:1.The 60 patients meeting the inclusion criteria of the disease were divided into two groups using the random number table.30 patients in treatment group and the others in control group.2.Medication notes:(1)Control group: supply shenshuaining capsule(Yunnan ideal Pharmaceutical Co.,Ltd.),(4 capsules,oral,three times a day),high-caliber and lower protein(0.6-0.8)G / kg.D),low salt diet,enough calories,symptomatic treatment.For example,blood pressure control,anemia treatment,anti infection,water electrolyte balance,acid-base balance in the body,and active control of the primary disease and its inducements(such as active control of blood glucose in diabetic patients).(2)Treatment group: all the treatments are the same with the control group,except for taking Shenqi Dihuang Decoction.3.Course of treatment: the observation course of the two groups was 8 weeks.4.By comparing the renal function(urea,SCR),blood routine,urine routine,endogenous creatinine clearance rate,24-hour urine protein quantity,Cystatin C,electrolyte,TCM syndrome score,liver function and other indicators before and after treatment,objectively describe the clinical effect and safety of the two groups.Result:1.Analysis of the total clinical efficacy between the two groups: the total effective percentage are 86.7%,and 63.3% in the treatment group and control group,respectively,which showed that the total effective percentage of the treatment group was higher with statistical sense(Z=-2.514,P =0.012 <0.05).2.Comparison of TCM syndrome efficacy2.1 Analysis of the total curative effect of TCM symptoms: the total effective percentage are 90% and 70% in the treatment group and control group,respectively.Two groups difference has statistical sense(P= 0.028 < 0.05).It is suggested that the treatment group in the total effective percentage of TCM symptoms is truly higher than the control group.2.2 TCM symptom score comparison: before and after the treatment,the comparison within the group and after the treatment,P < 0.05,the difference was statistically significant.The results showed that after treatment,the TCM symptom scores of the two groups were significantly reduced,in which the treatment group reduction percentage was higher than the control group.2.3 comparison of TCM symptoms: the difference of burnout,weakness of waist and knees,dry mouth and dry throat,five heart trouble and heat,clear length of night urine in the treatment group before and after treatment had statistical sense(P < 0.05).After treatment in control group,statistical differences in burnout,weakness of waist and knees,five heart trouble and heat have sense(P < 0.05);the difference in dry mouth and dry throat,clear length of night urine in control group have no sense(P > 0.05).After treatment in treatment and control group,the difference in burnout,weakness of waist and knees,dry mouth and dry throat,five heart trouble and heat,clear length of night urine have statistical sense between the groups(P < 0.05),which suggested that the TCM symptoms after treatment were intensely improved.The above statistics indicated that the improvement was exactly significant.3.Urine routine comparison: before and after treatment,the urine protein in the group was qualitative,24-hour urine protein quantitative comparison,after treatment,the group comparison,P value were all < 0.05,the difference was statistically significant.Before and after treatment,the results of urine RBC in the treatment group were statistically significant(P= 0.001 < 0.05),while in the control group(P= 0.292 > 0.05),the results were not statistically significant.By treatment,the group comparison,P= 0.017 < 0.05,the difference was quite significant.The results showed that the quality of urine protein and the quantity of 24-hour urine protein were alleviated in the treatment and control groups,besides,the treatment effect was better in the treatment group than the control group.The treatment extremely makes the number of urine RBC decreased in the treatment group,however,which had no effect on the number of urine RBC in the control group.4.Comparison of the clearance rate of endogenous creatinine: before and after treatment,the treatment group P= 0.000 < 0.05;he control group P= 0.042 <0.05.and after treatment,P= 0.035 < 0.05,with statistical significance.It is suggested that the improvement of clearance rate of endogenous creatinine in the treatment group is better than the control group.5.Comparison of renal function: before and after treatment,the comparison of serum creatinine,urea nitrogen and cystatin C was statistically significant(P <0.05).And after treatment,P= 0.038,0.042,0.043 < 0.05,with statistical significance.It is suggested that the treatment is effective on the improvement of serum creatinine,urea nitrogen and cystatin C,what's more,It's better in treatment group.6.Electrolyte comparison: There is no significant difference in concentration of K,Na,Cl,Mg before and after treatment in the treatment group,and the concentration of Ca and P have exactly improved(P < 0.05).However,no change appeared in the concentration of K,Na,Ca,Cl,P,Mg in the control group before and after treatment(P > 0.05).After treatment,K,Na,Cl,Mg were compared between the groups,P > 0.05,no statistical difference,Ca,P comparison,P value < 0.05,with statistical difference.Prompt treatment There was no significant change in K,Na,Cl,Mg,CA,P before and after treatment in the control group;there was no significant difference in K,Na,CA,Cl,P,Mg before and after treatment in the control group.There was no significant change in K,Na,Cl,Mg in the two groups after treatment.The Ca and P in the treatment group were significantly improved compared with the control group.7.Comparison of the statistic of ECG,blood routine,liver function and stool routine,we found that the differences have no statistical sense between the two groups before and after treatment(P > 0.05).During the whole treatment,there was no adverse reaction.Conclusion: Shenqi Dihuang Decoction have the improvement function of the clinical symptoms of patients who have the disease that is chronic renal failure,reducing proteinuria,and prolonging the occurrence of end-stage renal disease. |
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