Analysis On The Rapeutic Effect Of Q-switched Alexandrite Laser(755nm) In Thetreatment Of Café-au-lait Spots And Its Recurrence Influence Factors

Objective:To explore the therapeutic effect of café-au-lait spots treated by Q-switched alexandrite laser(755 nm),recurrence and the relationship between the influencing factors.Methods:496 patients who underwent café-au-lait spot treatment from January 2010 to January 2018 were selected as the research objects,and the Q-switched alexandrite laser(755 nm)was used for instrumentation.Through follow-up and consulting the outpatient medical records,the basic information of these patients,as well as the size,number,distribution,treatment effect,recurrence and complications of café-au-lait spots and other aspects of information were collected.According to the improvement of the lesion color,the therapeutic effect could be divided into four levels:ineffective,improved,effective and cured.The collected data was processed by SPSS22.0.Results:1、By analyzing the factors that affect the therapeutic effect and comparing café-au-lait spots with regular and irregular boundary,it was found that the effective rates of café-au-lait spots with regular and irregular boundary were 60.17%and 78.85%respectively,which was statistically significant(P<0.05);by comparing café-au-lait spots with even and uneven pigment,the effective rates of café-au-lait spots with even and uneven pigment were 64.05%and 79.47%respectively,which was statistically significant(P<0.05);the effective rates of small,medium and large lesions were 80.68%、66.67%and 61.29%,respectively;there was statistically significant difference between the small and the medium lesions(P<0.05);there was statistically significant difference between the small and the large lesions(P<0.05);there was no statistical correlation between the gender,age,the location of skin lesions,the color of skin lesions,the energy density,the number of treatment,the interval of treatment and the therapeutic effect(P>0.05).According to the correlation analysis of factors with statistical significance,the order of influence on the efficacy is:the area of skin lesions>the shape of skin lesions>the degree of pigment uniformity.2、By analyzing the factors that affect the therapeutic effect and comparing café-au-lait spots with regular and irregular boundary,the recurrence rate of café-au-lait spots with regular and irregular boundary was 48.73%and 39.62%,respectively(P<0.05);by comparing café-au-lait spots with even and uneven pigment,the recurrence rate of café-au-lait spots with even and uneven pigment was 48.04%and 37.37%respectively,which was statistically significant(P<0.05).The uniformity of pigment was closely related to the therapeutic effect.The recurrence rates of small,medium and large lesions were 30.11%,45.45%and 58.06%respectively,which had statistical significance(P<0.05).The recurrence rates of different therapeutic effects were 83.22%(ineffecti ve),46.79%(improved),19.51%(effective)and 14.86%(cured)respectively;the recurrence rate of ineffective patients was significantly higher than that of patients with other therapeutic effects,which was statistically significant(P<0.05);there was no statistical correlation between the color of skin lesions,location,energy density,.the number of treatment,treatment interval and recurrence(P>0.05).According to the correlation analysis of factors with statistical significance,the order of influence on recurrence is:curative effect>skin area>pigment uniformity>skin morphology.In this study,2 patients had long-term complications.Among them,l case was hypopigmentation,1 case suffered from chromatosis with secondary dermatitis.Conclusion:1、There is statistical correlation between the area,boundary and even pigment of café-au-lait spot and the therapeutic effect and recurrence.The café-au-lait spot with large area,regular boundary and uneven pigment have worse therapeutic effect and higher recurrence rate.2、There is a negative correlation between the therapeutic effect and the recurrence rate.3、It was preliminarily considered that the influence degree of the curative effect was as follows:lesion area>lesion shape>pigment uniformity.The influence degree of recurrence was:curative effect>lesion area>pigment uniformity>lesion shape.