Clinical Study Of Xingnaojing Injection Combined With Sodium Valproate On The Treatment Of Epilepsy With Phlegm And Fire Absentminded After Ischemic Stroke

Objective: To observe the clinical efficacy and safety of Xingnaojing Injection combined with Sodium Valproate on the treatment of phlegm and fire absentminded type of epilepsy after ischemic stroke,and its effect on serum inflammatory factors content.Methods: A randomized controlled clinical study was conducted to select 62 outpatients and inpatients with epilepsy after ischemic stroke who met the inclusion criteria from First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine.The patients were randomly divided into treatment group(31 cases)and control group(31 cases).The control group was treated with sodium valproate for anti-epilepsy,while the treatment group was treated with Xingnaojing Injection combined with Sodium Valproate for anti-epilepsy.Before and after treatment,seizure frequency,seizure time,TCM syndrome score,National Institutes of Health Stroke Scale,serum interleukin(IL)-1?,tumor necrosis factor(TNF)-?,and cyclooxygenase(COX)-2 contents,EEG,safety index and adverse reactions were observed and recorded to evaluate the clinical efficacy and safety of the prescription.Results: The 60 patients eligible for this study completed the trial.The two groups were statistically analyzed in terms of age,gender,underlying disease,course of disease,type of epilepsy,and evaluation indicators before treatment.The difference was significant(P > 0.05).After 2 weeks of treatment,theeffective rate of seizure control on the treatment group was 97% better than that in the control group 83%(P < 0.05);the scores of TCM syndromes,EEG and stroke scale of National Institutes of Health in the treatment group were better than those in the control group(P < 0.05);serum inflammatory factors content in the treatment group was significantly lower than that in the control group(P < 0.05).There was no significant difference in adverse reactions between the two groups(P > 0.05).Conclusion: Xingnaojing Injection combined with Sodium Valproateon the treatment of post-ischemic stroke epilepsy of phlegm and fire absentminded type has significant clinical efficacy,safe and reliable,can promote the recovery of nerve function,improve the quality of life of epilepsy patients,can reduce the level of inflammatory factors in serum of post-ischemic stroke epilepsy.