| Objective: To study the effects of statins on post stroke epilepsy(PSE).To explore the association between statins and PSE from the perspective of immune neuro endocrine-network(I-N-EN).Methods: 261 patients with ischemic stroke admitted to Department of Neurology,Qingdao Municipal Hospital,Medical Department of Qingdao University from January 2016 to June 2018 were enrolled in this study.The patients were divided into non-PSE group(stroke patients without epilepsy)and PSE group(stroke patients with epilepsy)according to their general situation.There were 151 patients in the non-PSE group(age:45-75,mean age: 61.32 ± 7.95,male: 90,female: 61)and 110 patients in the PSE group(age:45-75,mean age:59.81 ± 8.87,male: 72 and female: 38).All of them received routine neurological treatment.The patients with immune system diseases and malignant tumors were excluded according to the inclusion and exclusion criteria.The proportion of patients taking statins in the two groups and the serum levels of CRP,IgE,IgM,IgA and IgG of the patients who took statins from the two groups were compared.The National Institute of Health stroke scale(NIHSS)scores represented the severity of the neurology defect was analysed to evaluate the effect of statins on the severity of stroke and its relationship with PSE.The relationship between the cerebral cortex and lobes involved and PSE in the two groups by magnetic resonance imaging(MRI)was compared to revaluate the effect of statins on stroke site and its relationship with PSE.Results: There was no significant difference in age,sex ratio,and risk factors of stroke of patients between the two groups(P>0.05);and the difference was statistically significant in the rate of administration statin in the non-PSE group than that in the PSE group(χ2= 46.22,p<0.01).The serum level of CRP of the patients in the PSE group was significantly higher than that in the non-PSE group among the patients taking statins(t=2.12,p<0.05).The serum level of IgE of patients in the PSE group was significantly higher than that in the non-PSE group,the difference was statistically significant(t=2.32,p<0.05).There was no significant difference in the serum level of IgM,IgA,IgG of among the patients taking statins from between the non-PSE group and the PSE group(t=0.98,t=0.58,t=0.50,p>0.05).The proportion of patients with high NIHSS Scores of PSE group was significantly higher than that of non-PSE group with high proportion of statins,and the difference was statistically significant(χ2= 55.55,p<0.01).There were significant differences in the proportion of patients with cortex and lobe involvement in PSE groupr than that in non-PSE group with a high proportion of statins(χ2= 27.45,p<0.01;χ2= 32.19,p<0.01).Conclusion: There were some relationships between stroke and epilepsy to immune system and the immune state affected the prognosis of stroke,PSE patients with remarkably immune disorders.The severity of stroke and the ongoing of PSE were affected by whether statins were taken or not,meanwhile the NIHSS score was a good marker which represented the neurological functional defect of stroke patients.The higher the NIHSS score,the higher the occurrence of PSE.The severity of stroke and the incidence of PSE could reduced by taking statins.There was higher occurrence ratio in stroke patients involving cerebral cortex and lobes in the relationship between the local and PSE,the degree of cortical and lobar involvement and the occurrence of PSE could also reduced by taking statins.The statins may reduce the incidence of PSE through immunoregulation and it is the new target of future research and treatment of PSE.. |
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