The Therapeutic Effect Of Mongolian Medicine Liuwei Licorice Powder On The Gastrointestinal Side Effects Of Platinum-based Chemotherapy Drug Oxaliplatin

Objective:The therapeutic effect of Mongolian medicine liuwei licorice powder on the gastrointestinal side effects of platinum-based chemotherapy drug oxaliplatin.Methods:A total of 60 patients admitted to the Hematologic Oncology Department of Mongolian Medicine in our hospital from April 2018 to April 2020 and treated with platinum chemotherapy were randomly divided into a control group and an observation group.Patients in the control group were given intravenous infusion of Tropisetron injection before chemotherapy,patients in the observation group were given intravenous infusion of Tropisetron injection before chemotherapy,and at the same time,the Mongolian medicine Liuwei Licorice powder was taken orally for 5 days starting from the day of chemotherapy.The observation period was 5 days.The gastrointestinal toxic and side effects(nausea,vomiting,loss of appetite,diarrhea),KPS,PS,QOL,etc.,were observed before and from day 1 to day 5 after chemotherapy.Results:1.Comparison before treatment:There were no statistically significant differences in gender,age,height and weight between the two groups,indicating comparability.2.Comparison after treatment:Comparison of clinical efficacy of nausea symptoms:the total effective rate(73.33%,26.67%)of the observation group on the first day of chemotherapy,and the total effective rate(63.33%,36.67%)of the control group.On the second day of chemotherapy,the total effective rate of the observation group was 56.67%,with an incidence of 43.33%,while the total effective rate of the control group was 53.33%,with an incidence of 46.67%.On the third day of chemotherapy,the observation group had a total effective rate of 63.33%with an incidence of 36.67%,while the control group had a total effective rate of 56.67%with an incidence of 43.33%.On day 4 of chemotherapy,the observation group had a total effective rate of 93.33%with an incidence of 6.67%,while the control group had a total effective rate of 63.33%with an incidence of 36.67%.On the fifth day of chemotherapy,the total effective rate and incidence of the observation group were 100.00%and 0.00%,while the total effective rate and incidence of the control group were 83.33%and 16.67%.There was no significant difference on the first day after chemotherapy(P>0.05).The difference was statistically significant 2-5 days after chemotherapy(P<0,05).Comparison of clinical efficacy of vomiting:the total effective rate of the observation group on the first day of chemotherapy was 96.67%,with an incidence of 3.33%,while the total effective rate of the control group was 83.33%,with an incidence of 16.67%.On the second day of chemotherapy,the total effective rate of the observation group was 86.67%,with an incidence of 13.33%,while the total effective rate of the control group was 66.67%,with an incidence of 33.33%.On the third day of chemotherapy,the total effective rate of the observation group was 93.33%with an incidence of 6.67%,while the total effective rate of the control group was 60.00%with an incidence of 40.00%.On day 4 of chemotherapy,the observation group had a total effective rate of 96.67%with an incidence of 3.33%,while the control group had a total effective rate of 63.33%with an incidence of 36.67%.The total effective rate and incidence of the observation group were 100.00%and 0.00%respectively on day 5 of chemotherapy,and the total effective rate and incidence of the control group were 80.00%and 20.00%respectively.There was no significant difference on the first day after chemotherapy(P>0.05).The difference was statistically significant 2-5 days after chemotherapy(P<0.05).Comparative results of clinical efficacy of decreased appetite:the total effective rate of the observation group on the first day of chemotherapy was 86.67%,with an incidence of 13.33%,while the total effective rate of the control group was 66.67%,with an incidence of 33.33%.On the second day of chemotherapy,the total effective rate of the observation group was 83.33%,with an incidence of 16.67%,while the total effective rate of the control group was 43.33%,with an incidence of 56.67%.On the third day of chemotherapy,the total effective rate of the observation group was 76.67%,with an incidence of 23.33%,while the total effective rate of the control group was 40.00%,with an incidence of 60.00%.On day 4 of chemotherapy,the observation group had a total effective rate of 83.33%with an incidence of 16.67%,while the control group had a total effective rate of 53.33%with an incidence of 46.67%.On the fifth day of chemotherapy,the total effective rate of the observation group was 90.00%and the incidence was 10.00%,while the total effective rate of the control group was 86.67%and the incidence was 13.33%.There was no significant difference on the first day after chemotherapy(P>0.05).The difference was statistically significant 2-5 days after chemotherapy(P<0.05).Comparative results of clinical efficacy of diarrhea:the total effective rate and incidence rate of the observation group were 100.00%and 0.00%on the first day of chemotherapy,while the total effective rate and incidence rate of the control group were 86.67%and 13.33%respectively.On the second day of chemotherapy,the total effective rate of the observation group was 96.67%,with an incidence of 3.33%,while the total effective rate of the control group was 80.00%,with an incidence of 20.00%.On the third day of chemotherapy,the total effective rate of the observation group was 96.67%,with an incidence of 3.33%,while the total effective rate of the control group was 86.67%,with an incidence of 13.33%.On day 4 of chemotherapy,the observation group had a total effective rate of 96.67%with an incidence of 3.33%,while the control group had a total effective rate of 86.67%with an incidence of 13.33%.On the fifth day of chemotherapy,the total effective rate and incidence of the observation group were 100.00%and 0.00%,while the total effective rate and incidence of the control group were 93.33%and 6.67%.There was no statistically significant difference between 1-5 days after chemotherapy(P>0.05).But the total effective rate of the observation group was higher than that of the control group.Comparison of the total clinical efficacy of KPS:the total efficacy of the two groups was compared at P>.05,with no statistically significant difference.But the total effective rate of the observation group was higher than that of the control group.Comparison of PS clinical efficacy:the total effective rate of the observation group and the control group was 70.00%and 63.33%respectively on the first day of chemotherapy.The total effective rate was 70.00%in the observation group and 53.33%in the control group on the second day of chemotherapy.The total effective rate was 63.33%in the observation group and 40.00%in the control group on the third day of chemotherapy.The total effective rate was 83.33%in the observation group and 63.33%in the control group on day 4 of chemotherapy.The total effective rate was 96.67%in the observation group and 80.00%in the control group on the 5th day of chemotherapy.P>0.05 on day 1-5 after chemotherapy,the difference was not statistically significant.But the total effective rate of the observation group was higher than that of the control group.Comparison of clinical efficacy of QOL:the total effective rate of the observation group and the control group was 80.00%and 63.33%respectively on the first day of chemotherapy.The total effective rate was 76.67%in the observation group and 60.00%in the control group on the second day of chemotherapy.On the third day of chemotherapy,the total effective rate was 80.00%in the observation group and 56.67%in the control group.The total effective rate was 86.67%in the observation group and 66.67%in the control group on day 4 of chemotherapy.The total effective rate was 96.67%in the observation group and 83.33%in the control group on the fifth day of chemotherapy.P>0.05 on day 1-4 after chemotherapy,the difference was not statistically significant.P<0.05 on the 5th day after chemotherapy,the difference was statistically significant.3.Comparison of gastrointestinal adverse reactions between the two groups,the incidence of grade ? and above in the observation group was less than that in the control group.4.Comparative analysis of safety:there was no significant difference in blood routine,urine routine,liver and kidney function,coagulation and ion between the two groups(P>0.05).Conclusion:The Mongolian medicine Liuwei Licorice powder combined with Tropisetron injection has a better effect than the monotherapy group.It can effectively relieve gastrointestinal side effects and improve the quality of life of patients.