Study On Preparation And Properties Of Novel Antibacterial Polyurethane Composite Fibers

Bacterial infection has been one of major threats to human health worldwide.According to a released report,more than 2 million patients suffer the infection of various biological materials each year in the United States alone,resulting in more than 90,000 deaths.Moreover,an estimated additional 450-570 million of nursing expenses has caused great losses to the safety and economy of human society.Therefore,the continuous exploration and development of emerging antibacterial materials are of great social significance.Nano systems prepared through nanotechnologies can be precisely controlled in terms of physicochemical properties and thus exhibit many unique advantages.Currently,the design of antibacterial nanomaterials has become one of the hottest research topics in recent years.In this thesis,we designed and synthesized a novel N-halamine polymer,which was then processed into a nanofibrous membrane(NM).The active ingredient release of the NM was monitored during its antibacterial process and the reusability was also evaluated,confirming its potential value in the application of wound dressings.In addition,we fabricated a composite fiber containing antibacterial zirconium phosphate(Zr P)and antioxidative rhubarb powder(Rr),which possessed decent antibacterial and antioxidant properties,providing an idea of ??preparing composite functional fibers through a simple and scalable process.Therefore,the application of such functional composite fiber and its fabrics could be highly recommended in biomedical and packaging fields.The thesis is mainly divided into three parts:Part 1,based on the N-halamine unit of chlorinated 2,2,6,6-Tetramethyl-4-piperidinol,an autologous antibacterial polymer with polymethyl methacrylate(PMMA)as molecular backbone was designed and synthesized,the antibacterial activity of which was then demonstrated.Particularly,we grafted chlorinated 2,2,6,6-Tetramethyl-4-piperidinol monomer to the backbone ofPMMA through the transesterification reaction,the structure and antibacterial properties of synthesized polymer were characterized and confirmed,up to 99.99%with antibacterial rate.Part 2,employing the above synthetic antibacterial polymer,we fabricated a nanofibrous membrane(NM)using electrospinning technology which was expected to be used as wound dressing.In particular,we blended the antibacterial polymer(AP)and thermoplastic polyurethane(TPU),and the blend was further processed into NM.The release process of active ingredients and the recyclability(? 5 times)of the prepared NM were tracked and evaluated,which laid a certain foundation for the repeated use.Part 3,using antibacterial and antioxidant material as fillers,a simple and economical spinning method was used to prepare antibacterial and antioxidant fibers.In detail,micron-sized Rr and Zr P as fillers,a novel type of antibacterial and antioxidant composite functional fiber was facilely prepared by wet spinning technology,and the performance of antibacterial,antioxidant and washing resistance(? 10 times)were verified,demonstrating the yielded fiber could be potentially applied in the fields of biomedical textiles and food packaging materials.