Correlation Analysis Of Serum PGⅠ,PGⅡ And G-17 Levels With Gastric Precancerous Diseases And Precancerous Lesions

Objective:To analyze the correlation between serum levels of pepsinogen I（PG I）,pepsinogen II（PG II）,PG I/II（PGR）,gastrin-17（G-17）with different gastric precancerous diseases and precancerous lesions,and to explore the application value of PG and G-17 detection in the screening of precancerous diseases and lesions of gastric cancer.Methods:A total of 415 cases of GC screening among high-risk groups of gastric cancer（GC）in Longdong,Gansu Province from April 2018 to October 2018were selected as the research subjects.Grouped according to the results of gastroscopy and pathology:（1）Chronic non-atrophic gastritis（CNAG）group（control group）;（2）Peptic ulcer（PU）group;（3）Chronic atrophic gastritis（CAG）group;（4）Intestinal metaplasia（IM）Group;（5）Intraepithelial neoplasia（IN）group.According to the existence of gastric precancerous lesions:（1）non-precancerous lesions group（control group）;（2）precancerous lesions group.Time-resolved fluorescence microsphere immunochromatography and fluorescence immunochromatography were used to detect serum PG and G-17 concentrations,and ¹³C urea breath test(¹³C-UBT)was used to detect H.pylori（Hp）infection.Use SPSS 22.0 software for relevant data analysis.Results:Compared with the CNAG group,the levels of PG I and PGR in the CAG group decreased,and the difference was statistically significant（P<0.05）.In the CAG group,compared with the Hp-negative group,the Hp-positive group had higher levels of PG I,PG II,G-17,and lower PGR levels,and the difference was statistically significant（P<0.05）.The optimal cut-off values for predict of CAG by PG I and PGR are 117.60 ng/mL,8.90,AUC（95%CI）are 0.647（0.571⁰.724）,0.754（0.687⁰.821）,and sensitivity is 55.8%,53.9%,Specificity is 74.1%,89.7%,respectively.The AUC（95%CI）,sensitivity,and specificity of PG I combined with PGR to predict CAG were 0.752（0.684⁰.819）,57.8%,and 84.5%,respectively.Compared with the non-precancerous lesion group,the levels of PG I and PG II in the precancerous lesion group increased,and the difference was statistically significant（P<0.05）.The optimal cut-off values for predict of precancerous lesions by PG I and PG II are 128.25 ng/mL,36.415 ng/mL,AUC（95%CI）are 0.632（0.564⁰.700）,0.613（0.540⁰.685）,sensitivity They were 76.1%and 53.5%,and the specificities were 22.5%and 95.1%,respectively.The AUC（95%CI）,sensitivity,and specificity of PG I combined with PG II for the predict of precancerous lesions were 0.643（0.571⁰.715）,88.7%,and 34.3%,respectively.Conclusion:1.Decreased PG I and PGR levels may indicate the presence of CAG,and elevated PG I and PG II levels indicate the presence of gastric precancerous lesions.Hp infection may affect PG and G-17 levels.2.PG detection may have predictive value for CAG,IM,IN,but the sample size of this study is small,which is not enough to expand to the screening level.