Research On The Correlation Between Helicobacter Pylori Infection And Serum Lipid As Well As Blood Sugar In People With Physical Examination

Objective: By retrospective analysis of clinical data of physical examination personnel in our hospital nearly half a year,comparing the changes of serum lipid and fasting plasma glucose(FPG)levels in people with or without Helicobacter pylori(Hp).And adjusted the effects of age,sex,body mass index(BMI)and other factors on serum lipid as well as blood glucose levels,so as to understand the correlation between Hp infection and serum lipid as well as blood glucose metabolism in Fujian.Methods: People who had physical examinations in the physical examination center of our hospital were collected from June 2018 to December 2018,the number of people who detected 13 C or 14 C breath test,FPG,total cholesterol,low density lipoprotein cholesterol,high density lipoprotein cholesterol,triglyceride,apolipoprotein A,apolipoprotein B,Apo A1/B and FPG were 1910 cases.The differences between the negative and Hp positive groups were analyzed retrospectively,and the effects of gender,age and BMI were corrected.According to the degree of helicobacter pylori infection,the patients were divided into four groups: negative group,positive group,medium positive group and strong positive group.Comparing the differences between the groups in serum lipid and blood glucose,and correcting the effects of gender,age and BMI.Therefore,we can determine whether helicobacter pylori infection is independently correlated with blood lipid and blood glucose.Results:(1)In this group,743 cases were Hp infection and the infection rate was 38.9%,there was no significant gender difference between the negative and positive groups(P=0.314).The infection rate of adolescent group(41.59%)and middle-aged group(37.50%)was higher than that of elderly group(32.97%)with significant difference(P<0.001).There was no significant difference in infection rate between middle-aged group and adolescent group.(P=0.078)(2)BMI(23.74 ± 3.13 vs 23.4 ± 3.15,P=0.019),FPG(4.83 ± 1.25 vs 4.72 ± 0.96,P=0.042)in Hp-positive group were higher than those in negative group,and Age(42.06 ± 13.22 vs 43.5 ± 13.36,P=0.021),Apo A1/B(1.52 ± 0.46 vs 1.57 ± 0.45,P=0.048)were lower than those in negative group with significant differences.There was no significant difference in the levels of LDL-C,HDL-C,TG,TC and Apo A1,Apo B,between the two groups(P > 0.05).(3)In order to eliminate the influence of age and BMI on the analysis index,further linear correlation analysis showed that age was negatively correlated with blood Apo A1/B level and positively correlated with FPG,while BMI was negatively correlated with blood Apo A1/B level and positively correlated with FPG.Linear regression analysis was used to correct the effects of age and BMI on serum lipid and blood sugar.It was found that the Hp infection was associated with the decrease of Apo A1/B(P=0.02),and with the increase of fasting blood sugar(P=0.013),in addition,it was an independent risk factor.(4)After dividing patients with Hp infection into four groups: negative group,positive group,medium positive group and strong positive group,there was no significant increasing or decreasing trend was found in the estimated mean values of blood glucose and serum lipids after adjusting for gender,age and BMI.Conclusion:(1)Young and middle-aged people were susceptible to Hp infection,and the infection rate of Hp was similar between male and female.(2)The Hp infection was correlated with the increase of BMI and FPG as well as the decrease of Apo A1/B,but not with the levels of LDL-C,HDL-C,TG,TC and Apo A1 in this group.(3)After correcting the influence of age and BMI on serum lipid and blood sugar by linear regression analysis,it was found that Hp infection was an independent risk factor for the decrease of Apo A1/B and the increase of FPG.(4)The intensity of Hp infection has little correlation with serum lipid and blood FPG.