The Influence Of Helicobacter Pylori Infectionon Glucolipid Metabolism And Insulin Resistance

Objective :Diabetes is one of the current serious chronic disease threat to human health. Long-term high blood sugar will cause serious complications in heart, brain, kidney, eyes and nerves. It is affecting the quality of life of patients with diabetes seriously..In all types of diabetes, type 2 diabetes accounts for the majority, but the treatment of diabetes is relatively limited at present. In clinical treatment, very few drugs can improve insulin resistance. In recent years, many studies have found that H.pylori infection can increase the oxidative stress of the organization and the system, and oxidative stress are thought to be the root cause of insulin resistance, the damage of β cell, the abnormal glucose tolerance and type 2 diabetes. Our country is a high incidence of helicobacter pylori, and there is rarely domestic research. Therefore, this study intends to investigate the relationship between helicobacter pylori, glucolipid metabolism and insulin resistance, which targets for intervention for the early prevention of diabetes, new drug research. Method:Select 73 cases of healthy check-up(31 cases of male, 42 cases of female) as the research object. Collecting all person’s medical history, general situation, measuring blood pressure, taking a fasting venous blood and detecting the blood routine, urine routine, liver function, kidney function, blood glucose(FBG), triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL- C), low density lipoprotein cholesterol(LDL-C) and14C-urea breath test(14C-UBT) in the morning. All persons are divided into the observation group and the control group based on the result of the 14 C-urea breath test. The observation group has helicobacter pylori infection and the control group has not. Triglyceride/high-density lipoprotein cholesterol(TG/HDL-C) is used as evaluation index of insulin resistance. Making contrastanalysis between the two groups. Results:Helicobacter pylori infection can significantly raise the body fasting blood glucose in Chinese(P<0.05), and it may influence the glucolipid metabolism and increase the level of TG/HDL-C in women(P<0.05), but there is no statistical difference between Hp(+) and Hp(-) in man(P>0.05).