| Objective:By observing the difference and correlation of helicobacter pylori (Hp) infection, blood lipid and serum inflammatory indexes in different TCM syndrome type of atherosclerosis (AS) patients, to explore the possible pathogenic factors of the intravascular inflammatory response and lipid deposition in the AS patients. This study aims to provide the basis for the AS early prevention and progress delaying. At the same time, seek the objective basis and explore new train of thought for individualized treatment of traditional Chinese medicine with AS disease.Methods:According to the Inclusion and exclusion criteria, this study select 218 AS patients in Dongzhimen hospital and Daanshan health service center outpatient. Collect their general information and finish clinical research after the patients sign the informed consent. Meanwhile, select 35 healthy check-up people in Dongzhimen hospital outpatient as normal control group. Collect the venous blood of the patients in the morning, and detect the serum Hp specific antibody (HpIgG), inflammatory factors, blood lipids and blood clotting. Finally, analyze the collected data.Results:1 The AS patients include 91 male and 127 female cases. Their overall age is 44-80, and average is 61.03±11.02 years old. The control group include 17 male and 18 female cases. Their overall age is 44-80, and average is 61.06±8.97 years old. The age and gender distribution between AS group and normal control group have no statistical significance difference. The BMI average value of the AS patients is 25.75 ±2.38 kg/m2, and the BMI average value of the normal control group is 24.19 ± 2.64 kg/m2. There is no statistical significance difference between the two groups of the BMI average value. Most of the AS patients are high-school education cultural level and workers. In life habits aspects, more than half of the patients accustomed to a high-fat and high salt diet, and the exercise frequency of most patients are less than 2 times per week. Dyslipidemia is a significant basis disease of AS.2 The serum HpIgG level of the AS patients is significantly higher than the normal control group. The HpIgG content of AS patients did not have difference with different gender, age, and BMI.3 From high to low in the order, the TCM syndrome type distribution of 218 AS patients is:Qi deficiency and blood stasis>Deficiency of liver and kidney yin >Qi stagnation and blood stasis>Sputum-stasis stagnation>Deficiency of spleen and kidney yang. Different TCM syndrome type of the AS patients did not have difference in gender, age, and BMI.4 The serum HpIgG level of AS patients with different TCM syndrome types is different. The result from high to low in the order is:Deficiency of liver and kidney yin> Qi deficiency and blood stasis>Deficiency of spleen and kidney yang >Qi stagnation and blood stasis>Sputum-stasis stagnation>control group. The serum HpIgG level of deficiency of spleen and kidney yang, Deficiency of liver and kidney yin, Qi deficiency and blood stasis, and Qi stagnation and blood all obvious higher than control group. Besides, The serum HpIgG level of Deficiency of liver and kidney yin is higher than the Sputum-stasis stagnation and Qi stagnation and blood stasis.5 The serum lipid level of AS patients with different TCM syndrome types is different. The TC level from high to low in the order is:Qi deficiency and blood stasis>Deficiency of liver and kidney yin>Qi stagnation and blood stasis> Sputum-stasis stagnation>Def iciency of spleen and kidney yang>control group. Compared to the control group, Qi deficiency and blood stasis has a higher TC level. The TG level from high to low in the order is:Qi deficiency and blood stasis>Deficiency of liver and kidney yin>Qi stagnation and blood stasis> Sputum-stasis stagnation>Def iciency of spleen and kidney yang>control group. Compared to the control group, Deficiency of liver and kidney yin, Qi deficiency and blood stasis, Qi stagnation and blood stasis have a higher TG level. The HDL-C level from high to low in the order is:control group>Deficiency of liver and kidney yin>Deficiency of spleen and kidney yang>Sputum-stasis stagnation >Qi stagnation and blood stasis>Qi deficiency and blood stasis. The HDL-C level of Qi deficiency and blood stasis and Qi stagnation and blood stasis are both significant lower than control group. The LDL-C level from high to low in the order is:Sputum-stasis stagnation>Qi deficiency and blood stasis>Deficiency of liver and kidney yin>Qi stagnation and blood stasis>Deficiency of spleen and kidney yang>control group. The LDL-C level of Sputum-stasis stagnation, Qi deficiency and blood stasis are both significant higher than control group.6 The FIB level from high to low in the order is:Qi stagnation and blood stasis >Deficiency of liver and kidney yin>Qi deficiency and blood stasis> Sputum-stasis stagnation>Deficiency of spleen and kidney yang. Besides, the FIB level of Qi stagnation and blood stasis, Deficiency of liver and kidney yin are both significant higher than deficiency of spleen and kidney yang. The difference of Hcy, PT (S), PTR, APTT, TTs of AS patients with different TCM syndrome types are not statistically significant.7 The serum inflammatory factors level of AS patients with different TCM syndrome types is different. The sICAM-1 level from high to low in the order is:Deficiency of spleen and kidney yang>Deficiency of liver and kidney yin > Qi deficiency and blood stasis>Qi stagnation and blood stasis>Sputum-stasis stagnation>control group. The sICAM-1 level of Deficiency of spleen and kidney yang, Deficiency of liver and kidney yin, Qi deficiency and blood stasis, Qi stagnation and blood stasis are all obvious higher than control group. The sVCAM-1 level from high to low in the order is:Deficiency of liver and kidney yin>Qi stagnation and blood stasis>Qi deficiency and blood stasis>control group>Sputum-stasis stagnation>Deficiency of spleen and kidney yang. The sVCAM-1 level of Deficiency of liver and kidney yin is obvious higher than Deficiency of spleen and kidney yang and control group. The IL-6 level from high to low in the order is:Deficiency of liver and kidney yin>Deficiency of spleen and kidney yang>Qi deficiency and blood stasis>Sputum-stasis stagnation> Qi stagnation and blood stasis>control group. The IL-6 level of Deficiency of spleen and kidney yang, Deficiency of liver and kidney yin, Qi deficiency and blood stasis are all obvious higher than control group. There are no statistical differences in serum hs-CRP and TNF-a level with different TCM syndrome types.8 The serum HpIgG and TC, LDL-C level have a positive correlation. Rise as HpIgG level, TC and LDL-C level are gradually raised. There is no straight line correlation between the serum HpIgG level and other lipid index of AS patients.9 There is no straight line correlation with the serum HpIgG level and Hcy, blood clot index of AS patients.10 The serum HpIgG of AS patients and hs-CRP,sICAM-1,VCAM-1 level have a positive correlation. Rise as HpIgG level, hs-CRP, sICAM-1 and VCAM-1 level are gradually raised. There is no straight line correlation with the serum HpIgG level and IL-6, TNF-α of AS patients.Conclusion:1 Most of the AS patients are overweight, the BMI of AS patients is higher than the control group.2 Qi deficiency and blood stasis, Deficiency of liver and kidney yin are the most important TCM syndrome type of AS patients. The rise of TC level is closely related to Qi deficiency and blood stasis. The rise of TG level is closely related to Deficiency of liver and kidney yin, Qi deficiency and blood stasis and Qi stagnation and blood stasis. The reduce of HDL-C level is closely related to Qi deficiency and blood stasis, Qi stagnation and blood stasis. The rise of LDL-C level is closely related to Sputum-stasis stagnation and Qi deficiency and blood stasis.3 The rise of FIB level is closely related to Qi stagnation and blood stasis and Deficiency of liver and kidney yin. The rise of sICAM-1 and sVCAM-1 level is closely related to Deficiency of liver and kidney yin. Deficiency of spleen and kidney yang, Deficiency of liver and kidney yin, Qi deficiency and blood stasis are related to the IL-6 level.4 The serum HpIgG level of AS patients is higher than control group. The serum HpIgG level of AS patients with different TCM syndrome types is different. The serum HpIgG level of Deficiency of liver and kidney yin is higher than the Sputum-stasis stagnation and Qi stagnation and blood stasis. Deficiency of liver and kidney yin, Qi deficiency and blood stasis are closely related to the Hp infection of AS patients.5 Rise as HpIgG level, TC, LDL-C, hs-CRP, sICAM-1 and sVCAM-1 level are all raised.
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