Study On The Relationship Between Nonalcoholic Fatty Liver Disease And The Risk Of Gastroesophageal Reflux Disease

Objective:Study on the relationship between nonalcoholic fatty liver disease and the risk of gastroesophageal reflux diseaseMethods:From February 2018 to January 2020,960 patients with FibroScan were enrolled in the Department of Gastroenterology,China-Japan Union Hospital,Jilin University.The general data of the patients were recorded,including sex,age,body mass index(BMI),blood pressure,drinking history,smoking history and medication history.Laboratory examination: fasting blood glucose(FBG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),aspartate transaminase(AST),alanine transaminase(ALT).All patients were divided into NAFLD group and control group according to the cap value measured by FibroScan.According to the results of GERDQ,positive symptoms + negative symptoms + positive influence ≥ 8 points,suggesting the diagnosis of GERD.The general characteristics of the two groups were compared and analyzed by logistic regression analysis to determine whether NAFLD increased the incidence rate of gastroesophageal reflux disease.Results:1.The incidence of acid reflux and heartburn in NAFLD group was significantly different from that in control group(P<0.05).2.the incidence rate of GERD in NAFLD group was significantly different from that in control group(P<0.05).3.NAFLD is an independent risk factor of GERD after adjusting the influence of sex,age,blood pressure,triglyceride,total cholesterol,low-density lipoprotein,high-density lipoprotein,body mass index and other confounding factors.Conclusion:The incidence of acid reflux and heartburn in the NAFLD group was significantly higher than that in the control group.The incidence of GERD in the NAFLD group was significantly higher than that in the control group.NAFLD is an independent risk factor for GERD.